University of Groningen
Enantioselective liquid-liquid extractions
Pinxterhuis, Erik
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Publication date: 2018
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Pinxterhuis, E. (2018). Enantioselective liquid-liquid extractions: On the synthesis and application of chiral phosphoric acids. University of Groningen.
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Stellingen
behorende bij het proefschrift
Enantioselective liquid-liquid extractions
On the synthesis and application of chiral phosphoric acids
Erik Bert Pinxterhuis
1) Chemistry is performed inside a fume hood, not behind a computer. 2) Much catalysis literature lacks highly relevant parameters as space-
time-yield, catalyst lifetime and/or turnover frequency, while the ultimate goal of any catalysis research should be geared towards its industrial application.
3) The hype around the words green, sustainable, environmentally friendly and the superabundant use of superlatives ‘unprecedented’ and ‘unseen’, often used to get published in high ranking journals, generally
overshadows the actual novelty and impressiveness of the invention. 4) People who describe the use of intrinsically unstable, highly reactive
or combustible compounds as ‘cool’ have never actually handled such a compound, as their opinion would be quickly transformed into respect. 5) From a continuity perspective the loss of knowledge due to succession of /
graduation of Ph.D. students is devastating to any research group. 6) When publishing in a journal with the name ‘Journal of Separation
Science’, one should make sure a baseline separation has been achieved between the enantiomers in their chiral chromatography.
(Tong et al. J. Sep. Sci., 2017, 40, 8, 1843)
7) In a metal catalyzed Sp3-Sp3 and Sp2-Sp3 coupling or cross-coupling between an organic halide and an organometallic reagent, the need for a metal-free control experiment to rule out mechanisms according to Sn1 and Sn2 principles is a must. Lack thereof highly increases the doubt on the role of the catalyst. (Jia et al. Nat. Commun. 2016, 7, 10614)
8) All academically generated literature, especially if funded via governmental agencies, should be openly and freely accessible.
9) As knowledge keeps on growing, revisiting relatively old work can lead to surprisingly new insights. For example the retraction of a retraction of this Wittig paper:
(Künzi et al. Angew. Chem. Int. Ed., 2015, 54, 36, 10670 and Franzen et al. Angew. Chem. 1960, 72, 12, 417)
