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Geometrical variability of esophageal tumors and its implications for accurate
radiation therapy
Jin, P.
Publication date
2019
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Citation for published version (APA):
Jin, P. (2019). Geometrical variability of esophageal tumors and its implications for accurate
radiation therapy.
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Geometrical variability of esophageal tumors and its implications for accurate radiation therapy
Peng Jin
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to aaend the public defence
of my PhD thesis entitled
IIIIIIIIII
Geometrical variability
of esophageal tumors
and its implications
for accurate
radiation therapy
on ursday January
at : p.m. in the Agnietenkapel
University of Amsterdam
Oudezijds Voorburgwal
Amsterdam
AAerwards you are
kindly invited to the reception
Peng Jin
Fregatstraat
RC Utrecht
p.jin@me.com
m
Paranymphs
Stef Maree
Mélanie Machiels
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Geometrical variability of esophageal
tumors and its implications for accurate
radiation therapy
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Cover design
Peng Jin
Layout design
Peng Jin
Printed by
Ipskamp Printing BV, Enschede
ISBN
978-94-028-1332-6
The research described in this thesis was carried out at the department of Radiation
On-cology in the Amsterdam UMC (Location AMC), University of Amsterdam, Amsterdam,
the Netherlands.
Financial support for the research in this thesis was provided by Elekta AB, Stockholm,
Sweden. Printing of this thesis was partially sponsored by Elekta AB.
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Geometrical variability of esophageal tumors and its
implications for accurate radiation therapy
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel
op donderdag 31 januari 2019, te 12:00 uur
door
Peng Jin
geboren te Shandong
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Promotiecommissie:
Promotor: Prof. dr. C.R.N. Rasch AMC-UvA Copromotores: Dr. T. Alderliesten AMC-UvA Dr. M.C.C.M. Hulshof AMC-UvA Overige leden: Prof. dr. H.W.M. van Laarhoven AMC-UvA Prof. dr. ir. J. Sonke AMC-UvA Prof. dr. M.B. van Herk AMC-UvA Prof. dr. M. Verheij Vrije Universiteit Amsterdam Dr. K.J. Neelis Leids Universitair Medisch Centrum Faculteit der Geneeskunde
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Contents
Chapter 1 General introduction 9
Chapter 2 Reduced inter-observer and intra-observer delineation variation in esophageal cancer radiation therapy by use of fiducial markers 23
Chapter 3 Marker-based quantification of interfractional tumor position variation and the use of markers for setup verification in radiation therapy for esophageal
cancer 39
Chapter 4 Comparison of carina-based versus bony anatomy-based registration for setup verification in esophageal cancer radiation therapy 53
Chapter 5 Density override in treatment planning to mitigate the dosimetric effect in-duced by gastrointestinal gas in esophageal cancer radiation therapy 67
Chapter 6 Quantification of respiration-induced esophageal tumor motion using fidu-cial markers and four-dimensional computed tomography 85
Chapter 7 Tailoring four-dimensional cone-beam computed tomography acquisition set-tings for fiducial marker-based image guidance in radiation therapy 99
Chapter 8 Interfractional variability of respiration-induced esophageal tumor motion quantified using fiducial markers and four-dimensional cone-beam computed
tomography 117
Chapter 9 Dosimetric benefits of mid-position compared with internal target volume strategy for esophageal cancer radiation therapy 133
Chapter 10 General discussion 153
References 194
Summary 199
Samenvatting 205
Addendum List of publications 208
Portfolio 211
Curriculum vitae 215
