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Lung-protective perioperative mechanical ventilation
Hemmes, S.N.T.
Publication date
2015
Document Version
Final published version
Link to publication
Citation for published version (APA):
Hemmes, S. N. T. (2015). Lung-protective perioperative mechanical ventilation.
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Lung-protective perioperative
mechanical ventilation
Beyond the dangers of high tidals,
on the perils of PEEP
Sabrine N.T. Hemmes
U I T N O D I G I N G
voor het bijwonen van de openbare verdediging van het proefschrift LUNG-PROTECTIVE PERIOPERATIVE MECHANICAL VENTILATION van Sabrine Hemmes Op vrijdag 11 december 2015 om 13.00 uur
De Aula van de UvA
Oude Lutherse kerk Singel 411, Amsterdam
Aansluitend bent u van harte uitgenodigd voor
de receptie ter plaatse
Paranimfen:
Jet Heering hdheering@hotmail.com
06 - 14 77 53 37 Pieter Roel Tuinman prtuinman@hotmail.com 06 - 21 24 52 00 Sabrine Hemmes Vrolikstraat 232-1 1092TW Amsterdam s.hemmes@amc.nl
Lung-protective perioperative
mechanical ventilation
Beyond the dangers of high tidals,
on the perils of PEEP
COLOFON
Lung-protective perioperative mechanical ventilation
Academic thesis, University of Amsterdam, Amsterdam, The Netherlands ISBN: 978-94-6233-149-5
Author: Sabrine N.T. Hemmes Lay-out: Barbara ten Brink
Cover: Image by Heng Swee Lim - Website: http://www.ilovedoodle.com Print: Gildeprint, Enschede, The Netherlands
Copyright © 2015 Sabrine N.T Hemmes, Amsterdam, The Netherlands
All rights reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means, without written permission of the author.
Financial support for the publication of this thesis was kindly provided by: Universiteit van Amsterdam, Abbvie, Edwards Lifesciences, Chipsoft
LUNG-PROTECTIVE
PERIOPERATIVE MECHANICAL VENTILATION
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit
op vrijdag 11 december 2015, te 13.00 uur door Sabrine Nienke Tallechina Hemmes
PROMOTIECOMMISSIE
Promotores: prof. dr. M.J. Schultz Universiteit van Amsterdam
prof. dr. dr. M.W. Hollmann Universiteit van Amsterdam
Overige leden: prof. dr. L.P.H.J. Aarts Universiteit van Leiden
prof. dr. C. Boer Vrije Universiteit Amsterdam prof. dr. M.A. Boermeester Universiteit van Amsterdam prof. dr. G. Cinnella University of Foggia, Italy prof. dr. M.M. Levi Universiteit van Amsterdam prof. dr. W.S. Schlack Universiteit van Amsterdam prof. dr. M.B. Vroom Universiteit van Amsterdam Faculteit der Geneeskunde
CONTENTS
Chapter 1 General introduction and outline of the thesis
Chapter 2 Intraoperative ventilatory strategies to prevent postoperative pulmonary complications – a metaanalysis
Current Opinion in Anesthesiology 2013
Chapter 3 Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications – a comprehensive review of the role of tidal volume, positive end-expiratory pressure and lung recruitment manoeuvres
Anesthesiology 2015
Chapter 4 LAS VEGAS – Local assessment of ventilatory management during general anaesthesia for surgery and its effects on postoperative pulmonary complications: a prospective, observational, international, multicentre cohort study
European Journal of Anaesthesiology 2013
Chapter 5 Intraoperative ventilation strategies and patient outcomes following surgery: an international observational study (LAS VEGAS)
Manuscript submitted
Chapter 6 Protective ventilation with lower tidal volumes and high PEEP versus conventional ventilation with high tidal volume and low PEEP in patients under general anaesthesia for surgery: A systematic review and individual patient data metaanalysis
Anesthesiology 2015
Chapter 7 Rationale and study design of PROVHILO - a worldwide multicentre randomized controlled trial on protective ventilation during general anaesthesia for open abdominal surgery
Trials 2011 9 25 39 75 81 137 159
Chapter 8 High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial
Lancet 2014
Chapter 9 Positive end-expiratory pressure during surgery - Authors' reply
Lancet 2014
Chapter 10 Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and metaanalysis
Lancet Respiratory Medicine 2014
Chapter 11 Positive end – expiratory pressure following coronary artery bypass grafting
Minerva Anestesiologica 2012
Chapter 12 Summary and general discussion
Appendices
Nederlandse samenvatting
Contributing authors and affiliations Publications PhD Portfolio Curriculum Vitae Acknowledgements 177 215 223 251 267 284 296 302 304 308 310
