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HIV-1 latency in proliferating T cells

van der Sluis, R.M.

Publication date

2013

Link to publication

Citation for published version (APA):

van der Sluis, R. M. (2013). HIV-1 latency in proliferating T cells.

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CONTENTS

Chapter One General introduction 9

HIV-1 latency 15

Outline of this thesis 20

Chapter Two Quantitation of HIV-1 DNA with a sensitive

TaqMan assay that has broad subtype specificity 27

Chapter Three Latency profiles of full length HIV-1 molecular

clone variants with a subtype specific promoter 45

Chapter Four Dendritic cell-induced activation of latent

HIV-1 provirus in actively proliferating

primary T lymphocytes 65

Chapter Five LTR promoter characteristics and the latency

profile of the HIV-1 subtypes B and AE 93

Chapter Six Activation of latent HIV-1 provirus by different

dendritic cell subsets isolated from blood 115

Chapter Seven Further characterization of the

dendritic cell-mediated activation of latent

HIV-1 provirus in primary T lymphocytes 143

Chapter Eight Establishment and molecular mechanisms

of HIV-1 latency in T cells 167

Chapter Nine General discussion 181

Addendum Summary 191 Samenvatting 195 Dankwoord 200 PhD Portfolio 203 List of Publications 205 Curriculum vitae 207

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