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Epidemiological studies on viral infections and co-infections
Human immunodeficiency virus, hepatitis C virus and human papillomavirus
van Santen, D.K.
Publication date
2018
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Citation for published version (APA):
van Santen, D. K. (2018). Epidemiological studies on viral infections and co-infections:
Human immunodeficiency virus, hepatitis C virus and human papillomavirus.
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Statements – Stellingen
pertaining to this thesis – behorende bij dit proefschrift
Epidemiological studies on viral infections and co-infections
human immunodeficiency virus, hepatitis C virus, human papillomavirus
Daniëla K. van Santen, 4th of May 2018
1. A high HIV viral load is associated with incident HCV infection, suggesting a biological role of HIV on HCV acquisition.
This thesis
2. Incident HCV infection leads to a temporary drop of CD4 T-cell counts among HIV-positive individuals. This thesis
3. HIV infection increases the risk of human papillomavirus acquisition and persistence. This thesis
4. The decrease in excess mortality over time among people who use drugs in Amsterdam is largely attributable to the decline in mortality among women.
This thesis
5. More than half of HCV-infected people who use drugs living in Amsterdam have moderate to severe liver fibrosis or cirrhosis.
This thesis
6. In a stable HCV epidemic, treatment with direct-acting antivirals is cost-saving among people who inject drugs, while in a declining epidemic it is cost-effective.
This thesis
7. Uptake of direct-acting antivirals was low among people who use drugs in Amsterdam in the first full year of its availability.
This thesis
8. In the Netherlands, the second WHO viral hepatitis elimination target – i.e. 65% reduction in HCV-related mortality by 2030 – will probably not be achieved among people who use drugs.
This thesis
9. Viral hepatitis kills more people than HIV and malaria. Global Disease Burden study
10. No elimination without decriminalization! Hepatitis Community statement
11. “I believe in being truthful, not neutral”. Christiane Amanpour
