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UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)

UvA-DARE (Digital Academic Repository)

B cells and B cell directed therapies in rheumatoid arthritis: towards

personalized medicine

Thurlings, R.M.

Publication date

2011

Link to publication

Citation for published version (APA):

Thurlings, R. M. (2011). B cells and B cell directed therapies in rheumatoid arthritis: towards

personalized medicine.

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PAGE. 

B CELLS AND B CELL

DIRECTED THERAPIES IN

RHEUMATOID ARTHRITIS

TOWARDS PERSONALIZED MEDICINE

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PAGE. 

PAGE. 

The studies performed in this thesis were performed at the Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, the Netherlands

COVER CREDITS: L.J DEN BREEIJEN HAS RHEUMATOID ARTHRITIS SINCE AROUND 40 YEARS. HE UNDERWENT SEVERAL OPERATIVE PROCEDURES ON HIS RIGHT WRIST AND ELBOW. DESPITE A DESTRUCTIVE DISEASE COURSE HE HAS CONTINUED TO WORK AS A CONSTRUCTION SITE MANAGER AT THE HOOGEHOVENS UNTIL THE AGE OF 57. HE IS AN ENTHOUSIASTIC SEA SWIMMER AND SAILOR AND HAS ALWAYS ENJOYED LIFE DESPITE HIS DISABILITIES. HE PARTICIPATED IN A CLINICAL TRIAL DESCRIBED IN THIS THESIS.

PRINTING OF THIS THESIS WAS FINANCIALLY SUPPORTED BY PFIZER B.V., ROCHE B.V., MERCK SHARP & DOHME B.V., ABBOTT B.V., SANOFI AVENTIS B.V., THE UNIVERSITY OF AMSTERDAM, HET TERGOOI ZIEKENHUIS AND HET REUMAFONDS

© 00 ROGIER M. THURLINGS, AMSTERDAM, THE NETHERLANDS. COVER DESIGN: MARTIJN MULDER, SARAH HEIJSE

LAY-OUT: BEAUTFUL MINDS

PRINTED BY: GVO DRUKKERS & VORMGEVERS B.V. | PONSEN & LOOIJEN ISBN:

B CELLS AND B CELL

DIRECTED THERAPIES IN

RHEUMATOID ARTHRITIS

TOWARDS PERSONALIZED MEDICINE

Ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus prof. dr. D.C. van den Boom

ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te

verdedigen in de Agnietenkapel op donderdag 13 januari 2010, te 14.00 uur

Door Rogier Martijn Thurlings geboren te Alkmaar

ACADEMISCH PROEFSCHRIFT

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PAGE. 4PAGE. 5

PROMOTIECOMMISSIE

PROMOTOR Prof. dr. P.P. Tak CO-PROMOTOR Dr. K. Vos CO-PROMOTOR Dr. D.M. Gerlag OVERIGE LEDEN Prof. R.J.M. ten Berge Prof. M.H.J. van Oers Prof. R.A.W. van Lier Prof. A.B.J. Prakken

Prof. J.M. van Laar Dr. S.M. van Ham Faculteit der Geneeskunde, Universiteit van Amsterdam

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