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Explorations of the therapeutic potential of influencing metabolism during critical

illness

Aslami, H.

Publication date

2013

Link to publication

Citation for published version (APA):

Aslami, H. (2013). Explorations of the therapeutic potential of influencing metabolism during

critical illness.

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Contents

Chapter 1 General outline of the thesis 9

Chapter 2 Targeting mitochondrial function in sepsis 17

Netherlands Journal of Critical Care, August 2012

Chapter 3 Induction of a hypometabolic state during critical illness – 35 a new concept in the ICU?

The Netherlands Journal of Medicine, May 2010

Chapter 4 Potential applications of hydrogen sulfide–induced suspended 53 animation

Current Medicinal Chemistry, June 2009

Chapter 5 Mild hypothermia reduces Ventilator−Induced Lung Injury, 75 irrespective of reducing respiratory rate

Translational Research, February 2012

Chapter 6 Induced hypothermia is protective in a rat model of pneumococcal 89 pneumonia associated with increased adenosine triphosphate

availability and turnover

Critical Care Medicine, March 2012

Chapter 7 The effect of induced hypothermia on respiratory parameters in 107 mechanically ventilated patients

Resuscitation, December 2010

Chapter 8 Induced hypothermia reduces the level of circulating mitochondrial 115 DNA in survivors of a cardiac arrest

Submitted

Chapter 9 Suspended animation inducer hydrogen sulfide is protective in an 125 in vivo model of ventilator–induced lung injury

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Chapter 10 Hydrogen sulfide donor NaHS reduces organ injury in pneumosepsis, 141 associated with improved bio–energetic status

Submitted

Chapter 11 A short course of hydrogen sulfide reduces organ injury in 167 endotoxemia, with no additional protection from prolonged infusion

Cytokine, December 2012

Chapter 12 Pharmacological induction of a hypo–metabolic state with 189 3–iodothyronamine is not protective in a mouse model of LPS

induced lung injury

Submitted

Chapter 13 Summary and general discussion 203

Appendix A Nederlandse samenvatting 209

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