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The inflammable truth of atherosclerosis
Verweij, S.L.
Publication date
2018
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Citation for published version (APA):
Verweij, S. L. (2018). The inflammable truth of atherosclerosis.
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THE INFLAMMABLE TRUTH OF
ATHEROSCLEROSIS
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Author: Simone Verweij Cover: Caroline Bruikman >ĂLJŽƵƚ͗^ŝŵŽŶĞsĞƌǁĞŝũ WƌŝŶƟŶŐ͗ZŝĚĚĞƌƉƌŝŶƚ ISBN-978-94-6375-001-1 &ŝŶĂŶĐŝĂůƐƵƉƉŽƌƚďLJƚŚĞƵƚĐŚ,ĞĂƌƚ&ŽƵŶĚĂƟŽŶĨŽƌƚŚĞƉƵďůŝĐĂƟŽŶŽĨƚŚŝƐƚŚĞƐŝƐŝƐŐƌĂƚĞĨƵůůLJ acknowledged. &ƵƌƚŚĞƌ ĮŶĂŶĐŝĂů ƐƵƉƉŽƌƚ ĨŽƌ ƉƌŝŶƟŶŐ ƚŚŝƐ ƚŚĞƐŝƐ ǁĂƐ ŬŝŶĚůLJ ƉƌŽǀŝĚĞĚ ďLJ ƚŚĞ D͕ tĞƐƞƌŝĞƐŐĂƐƚŚƵŝƐ͕ ŚŝƉƐŽŌ͕ ^ĂŶŽĮ ĂŶĚ ^ƟĐŚƟŶŐ ƚŽƚ ^ƚĞƵŶ WƌŽŵŽǀĞŶĚŝ sĂƐĐƵůĂŝƌĞ Geneeskunde.
THE INFLAMMABLE TRUTH OF
ATHEROSCLEROSIS
D/^,WZK &^,Z/&d
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
ŽƉŐĞnjĂŐǀĂŶĚĞZĞĐƚŽƌDĂŐŶŝĮĐƵƐ ƉƌŽĨ͘Ěƌ͘ŝƌ͘<͘/͘:͘DĂĞdž
ƚĞŶŽǀĞƌƐƚĂĂŶǀĂŶĞĞŶĚŽŽƌŚĞƚŽůůĞŐĞǀŽŽƌWƌŽŵŽƟĞƐŝŶŐĞƐƚĞůĚĞĐŽŵŵŝƐƐŝĞ͕ in het openbaar te verdedigen in de Agnietenkapel
ŽƉǁŽĞŶƐĚĂŐϱƐĞƉƚĞŵďĞƌϮϬϭϴ͕ƚĞϭϰ͗ϬϬƵƵƌ
door
Simone Léonie Verweij
WƌŽŵŽƟĞĐŽŵŵŝƐƐŝĞ͗ WƌŽŵŽƚŽƌ͗ WƌŽĨ͘Ěƌ͘ ͘^͘'͘^ƚƌŽĞƐ DͲhǀ ŽƉƌŽŵŽƚŽƌĞƐ͗ ƌ͘^͘:͘ĞƌŶĞůŽƚDŽĞŶƐ DͲhǀ ƌ͘,͘:͘sĞƌďĞƌŶĞ DͲhǀ KǀĞƌŝŐĞůĞĚĞŶ͗ WƌŽĨ͘Ěƌ͘:͘ŽŽŝũ DͲhǀ WƌŽĨ͘Ěƌ͘:͘:͘WŝĞŬ DͲhǀ WƌŽĨ͘Ěƌ͘&͘:͘ĞŵĞůŵĂŶ DͲhǀ WƌŽĨĚƌ͘D͘W͘:͘ĚĞtŝŶƚŚĞƌ DͲhǀ
Prof. dr. P. Knaapen Vrije Universiteit Amsterdam
ƌ͘:͘͘ǀĂŶƵƵů ^ĂŶƋƵŝŶ
TABLE OF CONTENTS
ŚĂƉƚĞƌϭ 'ĞŶĞƌĂůŝŶƚƌŽĚƵĐƟŽŶĂŶĚŽƵƚůŝŶĞŽĨƚŚĞƚŚĞƐŝƐ ϵ WĂƌƚ/ /ŵĂŐŝŶŐŽĨŵƵůƟͲůĞǀĞůŝŶŇĂŵŵĂƟŽŶŝŶĐĂƌĚŝŽǀĂƐĐƵůĂƌĚŝƐĞĂƐĞ ŚĂƉƚĞƌϮ dŚƌĞƐŚŽůĚƐĨŽƌĂƌƚĞƌŝĂůǁĂůůŝŶŇĂŵŵĂƟŽŶƋƵĂŶƟĮĞĚďLJ ϭϳ 18&Ͳ&'W dͬdŝŵĂŐŝŶŐ͗ŝŵƉůŝĐĂƟŽŶƐĨŽƌǀĂƐĐƵůĂƌ ŝŶƚĞƌǀĞŶƟŽŶĂůƐƚƵĚŝĞƐ ŚĂƉƚĞƌϯ /ŶĐƌĞĂƐĞĚŚĞŵĂƚŽƉŽŝĞƟĐĂĐƟǀŝƚLJŝŶƉĂƟĞŶƚƐǁŝƚŚ ϰϯ atherosclerosis ŚĂƉƚĞƌϰ WƌŽůŽŶŐĞĚŚĞŵĂƚŽƉŽŝĞƟĐĂŶĚŵLJĞůŽŝĚĐĞůůƵůĂƌƌĞƐƉŽŶƐĞ ϲϱ ŝŶƉĂƟĞŶƚƐĂŌĞƌĂŶĂĐƵƚĞĐŽƌŽŶĂƌLJƐLJŶĚƌŽŵĞŵĞĂƐƵƌĞĚ with 18&ͲWͲϳϭϰW dͬd ŚĂƉƚĞƌϱ ZϮĞdžƉƌĞƐƐŝŽŶŽŶĐŝƌĐƵůĂƟŶŐŵŽŶŽĐLJƚĞƐŝƐĂƐƐŽĐŝĂƚĞĚ ϴϵ ǁŝƚŚĂƌƚĞƌŝĂůǁĂůůŝŶŇĂŵŵĂƟŽŶĂƐƐĞƐƐĞĚďLJ18&Ͳ&' W dͬdŝŶƉĂƟĞŶƚƐĂƚƌŝƐŬĨŽƌĐĂƌĚŝŽǀĂƐĐƵůĂƌĚŝƐĞĂƐĞ WĂƌƚ// DĞĚŝĂƚŽƌƐŽĨƚŚĞŝŶŇĂŵŵĂƚŽƌLJƌĞƐƉŽŶƐĞŝŶĐĂƌĚŝŽǀĂƐĐƵůĂƌĚŝƐĞĂƐĞ ŚĂƉƚĞƌϲ ZĞŵŶĂŶƚĐŚŽůĞƐƚĞƌŽůĞůŝĐŝƚƐĂƌƚĞƌŝĂůǁĂůůŝŶŇĂŵŵĂƟŽŶ ϭϭϭ ĂŶĚĂŵƵůƟůĞǀĞůĐĞůůƵůĂƌŝŵŵƵŶĞƌĞƐƉŽŶƐĞŝŶŚƵŵĂŶƐ ŚĂƉƚĞƌϳ ůĞǀĂƚĞĚůŝƉŽƉƌŽƚĞŝŶ;ĂͿůĞǀĞůƐĂƌĞĂƐƐŽĐŝĂƚĞĚǁŝƚŚĐŽƌŽŶĂƌLJ ϭϯϱ ĂƌƚĞƌLJĐĂůĐŝƵŵƐĐŽƌĞƐŝŶĂƐLJŵƉƚŽŵĂƟĐŝŶĚŝǀŝĚƵĂůƐǁŝƚŚĂ ĨĂŵŝůLJŚŝƐƚŽƌLJŽĨƉƌĞŵĂƚƵƌĞĂƚŚĞƌŽƐĐůĞƌŽƟĐĐĂƌĚŝŽǀĂƐĐƵůĂƌ disease ŚĂƉƚĞƌϴ ƌƚĞƌŝĂůĂŶĚĐĞůůƵůĂƌŝŶŇĂŵŵĂƟŽŶŝŶƉĂƟĞŶƚƐǁŝƚŚ< ϭϱϭŚĂƉƚĞƌϵ Secukinumab treatment decreases arterial wall 173 ŝŶŇĂŵŵĂƟŽŶŝŶƉĂƟĞŶƚƐǁŝƚŚƉĞƌŝƉŚĞƌĂůƐƉŽŶĚLJůŽĂƌƚŚƌŝƟƐ ŚĂƉƚĞƌϭϬ ^ƵŵŵĂƌLJ͕ĚŝƐĐƵƐƐŝŽŶĂŶĚĐůŝŶŝĐĂůŝŵƉůŝĐĂƟŽŶƐ ϭϴϱ ĚĚĞŶĚĂ EĞĚĞƌůĂŶĚƐĞƐĂŵĞŶǀĂƫŶŐ ϭϵϴ ƵƚŚŽƌƐĂŶĚĂĸůŝĂƟŽŶƐ ϮϬϯ WŽƌƞŽůŝŽĂŶĚůŝƐƚŽĨƉƵďůŝĐĂƟŽŶƐ ϮϬϳ
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