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Degradation of the endothelial glycocalyx by atherogenic factors. Microvascular
functional implications
Constantinescu, A.A.
Publication date
2002
Link to publication
Citation for published version (APA):
Constantinescu, A. A. (2002). Degradation of the endothelial glycocalyx by atherogenic
factors. Microvascular functional implications.
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Contents s
ii General Introduction 11 1.11 The endothelial glycocalyx as a component of the vessel wall 12
1.22 Historical view on the endothelial glycocalyx 13 1.33 Characterization of the endothelial glycocalyx 14 1.44 Composition of the endothelial glycocalyx 19 1.55 Physiological roles of the endothelial glycocalyx 26
1.66 Aim of the study 36 1.77 Outline of the study 38
Referencess 39 22 Oxidized lipoproteins degrade the endothelial surface layer;
Im-plicationss for platelet-endothelial cell adhesion 47
CirculationCirculation (2000) 101: 1500-1502. Abstractt 48 2.11 Introduction 49 2.22 Methods 49 2.33 Results 51 2.44 Discussion 51 Referencess 54 33 Elevated capillary tube hematocrit reflects degradation of the
gly-cocalyxx by oxidized low density lipoproteins 57
Am.Am. J. Physiol. Heart Circ. Physiol. (2001) 280: H1051-H1057
Abstractt 58 3.11 Introduction 59
3.22 Materials and Methods 60
3.33 Results 63 3.44 Discussion 66
88 Contents
Referencess 71 44 Degradation of the endothelial glycocalyx promotes leukocyte
-endotheliall cell adhesion 75 Submittedd for publication
Abstractt 76 4.11 Introduction JJ
4.22 Materials and Methods 78
4.33 Results 81 4.44 Discussion 86 Referencess 90 55 Degradation of the endothelial glycocalyx is associated with
suben-dotheliall accumulation of chylomicrons in capillaries of
hyper-lipidemicc mice 93
Submittedd for publication
Abstractt 94 5.11 Introduction 95
5.22 Materials and Methods 95
5.33 Results 99 5.44 Discussion 104 5.55 Acknowledgements 109
Referencess 109 66 Hyperlipidemia induced degradation of the endothelial
glycoca-lyxx abolishes vasodilator modulation of perfused capillary
vol-umee 111 Submittedd for publication
Abstractt 112 6.11 Introduction 113
6.22 Materials and methods 114
6.33 Results 117 6.44 Discussion 124 Referencess 130 77 General Discussion 133
7.11 Endothelial dysfunction in atherogenesis 134 7.22 Degradation of the endothelial glycocalyx by Ox-LDL 134
'j.j,'j.j, Degradation of the endothelial glycocalyx stimulates
leuko-cytee - endothelial adhesion 136 7.44 Glycocalyx degradation during diet-induced hyperlipidemia 137
7.55 Perspectives for endothelial glycocalyx investigation in large vesselss 140 7.66 Conclusions 141 Referencess 142 Summaryy 147 Nederlandsee Samenvatting 151 Dankwoordd 155 Curriculumm Vitae 159
