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Expression profiling in head and neck cancer: Predicting response to
chemoradiation
Pramana, J.
Publication date
2014
Document Version
Final published version
Link to publication
Citation for published version (APA):
Pramana, J. (2014). Expression profiling in head and neck cancer: Predicting response to
chemoradiation.
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Jimmy
Pra
Expression profiling in head and
neck cancer: predicting response to
chemoradiation
Expression profiling in head and neck cancer: predicting response to chemoradiation © Jimmy Pramana, Amstelveen, 2014
printed by: Ipskamp drukkers, Enschede
cover design: Anton Westbroek, www.anton-kunst.nl Lay-out: Alex Wesselink, persoonlijkproefschrift.nl
The research described in this thesis was performed at the division of Experimental Therapy of the Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
This project was financially supported by the Dutch Cancer Society (Grant NKI 2005-3420)
Printing of this thesis was financially supported by: -KWF kankerbestrijding
-Entermed -Specsavers -KNO-winkel.nl
-NSvG, Patientvereniging voor stembandlozen -Zeiss
Expression profiling in head and neck cancer:
predicting response to chemoradiation
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
Prof. dr. D.C. van den Boom
ten overstaan van een door het college voor promoties ingestelde
commissie, in het openbaar te verdedigen in de Aula der
Universiteit op vrijdag 17 oktober 2014 te 13.00 uur
door Jimmy Pramana
Promotores: Prof. dr. M.W.M. van den Brekel Prof. dr. A.C. Begg†
Co-promotores: Prof. dr. C.R.N. Rasch Prof. dr. A.J.M. Balm
Overige leden: Prof. dr. L.E. Smeele Prof. dr. M.J. van de Vijver Prof. dr. R.H. Brakenhoff Prof. dr. M Verheij Dr. V.B. Wreesmann Faculteit der Tandheelkunde
Contents Chapter 1:
Introduction and outline of the thesis
Chapter 2:
Heterogeneity of gene expression profiles in head and neck cancer
Chapter 3:
Gene expression profiling to predict outcome after chemoradiation in head and neck cancer
Chapter 4:
A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation
Chapter 5:
HPV and high risk gene expression profiles predict response to chemoradiation in head and neck cancer, independent of clinical factors
Chapter 6:
EGFR expression predicts unfavourable survival in advanced HPV-positive oropharyngeal cancer treated with chemoradiation
Chapter 7: General Discussion Chapter 8: Summary/Samenvatting Appendices: Curriculum Vitae List of publications Dankwoord Color section 7 23 37 59 77 93 111 119 128 129 130 134
