University of Groningen
From single-drug pharmacokinetics and pharmacodynamics to multi-drug interaction
modeling: using population-based modeling to increase accuracy of anesthetic drug titration
Hannivoort, Laura Naomi
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hannivoort, L. N. (2018). From single-drug pharmacokinetics and pharmacodynamics to multi-drug
interaction modeling: using population-based modeling to increase accuracy of anesthetic drug titration:
"Surfing the wave". Rijksuniversiteit Groningen.
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Stellingen behorend bij het proefschrift
From single-drug pharmacokinetics and pharmacodynamics to multi-drug interaction modeling: using population-based modeling to increase accuracy of anesthetic drug titration
Laura N. Hannivoort 26 juni 2018
1) All models are wrong, but some are useful - George Box
2) As yet unidentified factors within an individual changing over time can have a greater influence on pharmacokinetic model parameters than differences between individuals - This thesis 3) Stimulation of a person under dexmedetomidine sedation increases the BIS acutely, after which
the person ‘falls back to sleep’, in 1 to 35 minutes - This thesis
4) Background noise makes a person under dexmedetomidine sedation more susceptible to the sedative effects when assessed by MOAA/S score - This thesis
5) The two mean arterial blood pressure effect-site compartments in dexmedetomidine PKPD explain both the initial fast infusion hypertension and the high concentration hypertension, and correspond with the different physiologic substrates for receptor activation for hypo- and hypertension - This thesis
6) Deep sedation with dexmedetomidine corresponds well with normalization of the mean arterial blood pressure – the phase between hypotension at low concentrations and hypertension at high concentrations – but does induce bradycardia - This thesis
7) Beware the post-dexmedetomidine hypotension! - This thesis
8) Although opioids are known to have a large effect on probability of tolerance of noxious stimuli, they only have minimal influence on EEG-derived measurements of hypnotic drug effect - This thesis
9) Interaction model-based calculated parameters (PTOL, NSRI) are better predictors of tolerance of
noxious stimuli than current measurements of components of anesthesia - This thesis 10) Science may be described as the art of oversimplification - Karl Popper
11) There is no delusion more damaging than to get the idea in your head that you understand the
