• No results found

Retrospective evaluation of the Dutch pre-newborn screening cohort for propionic acidemia and isolated methylmalonic acidemia: What to aim, expect, and evaluate from newborn screening?

N/A
N/A
Protected

Academic year: 2021

Share "Retrospective evaluation of the Dutch pre-newborn screening cohort for propionic acidemia and isolated methylmalonic acidemia: What to aim, expect, and evaluate from newborn screening?"

Copied!
15
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)University of Groningen. Retrospective evaluation of the Dutch pre-newborn screening cohort for propionic acidemia and isolated methylmalonic acidemia Haijes, Hanneke A.; Molema, Femke; Langeveld, Mirjam; Janssen, Mirian C.; Bosch, Annet M.; van Spronsen, Francjan; Mulder, Margot F.; Verhoeven-Duif, Nanda M.; Jans, Judith J. M.; van der Ploeg, Ans T. Published in: Journal of Inherited Metabolic Disease DOI: 10.1002/jimd.12193 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.. Document Version Publisher's PDF, also known as Version of record. Publication date: 2020 Link to publication in University of Groningen/UMCG research database. Citation for published version (APA): Haijes, H. A., Molema, F., Langeveld, M., Janssen, M. C., Bosch, A. M., van Spronsen, F., Mulder, M. F., Verhoeven-Duif, N. M., Jans, J. J. M., van der Ploeg, A. T., Wagenmakers, M. A., Rubio-Gozalbo, M. E., Brouwers, M. C. G. J., de Vries, M. C., Langendonk, J. G., Williams, M., & van Hasselt, P. M. (2020). Retrospective evaluation of the Dutch pre-newborn screening cohort for propionic acidemia and isolated methylmalonic acidemia: What to aim, expect, and evaluate from newborn screening? Journal of Inherited Metabolic Disease, 43(3), 424-437. https://doi.org/10.1002/jimd.12193. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.. Download date: 25-06-2021.

(2) d@A@CT@Vt_qfcKcLB[q>p d@TCL@Vt>e{ABDH@O[q>p fAA@NB@Vt>[ZDT@PH@O[q>p J{ht>qr>qq[iCPVr>[>p_. 012324565172869. 1

(3)   .       

(4)  

(5)  

(6).  

(7) 

(8) 

(9)          !" # $  # . 

(10)   

(11) 

(12). % & ' 5(&) *#+ , - ' .  / , .

(13) ) 6  0 , .

(14) 8(1 2 , 5 .(3 4 , -

(15) )5

(16)  6 , .

(17)  -(.

(18) 7 , 4.(8

(19)   * , 1 1(.(1* , 57(

(20) 9 / , .

(21) 

(22). 5(" '

(23) : , .(9 1 3 ; *< , .

(24) )8(3(1(3

(25) 

(26) ** , .' 8( 8

(27)  *+ , 1 ' 3(6  ': , . = "/ , 9.

(28) .(&  + >?@AB CDEF@BGHDICAJCGKEDLBCALMJ@NGOBP@EBDQR@E@BCALMSECT@OLCBUF@VCAGIW@EBO@SBO@AXBMSBO@AXBSECT@OLCBUMSBO@AXBMYX@Z@BX@OIGEVL [?@AB CDEF@BGHDICAJCL@GL@LMJ@NGOBP@EBDQWXCIV\@GIBXM]CIX@IPCEGWXCIVO@E^L\DLNCBGIMSECT@OLCBUF@VCAGIW@EBO@SBO@AXBMSBO@AXBSECT@OLCBUM. SBO@AXBMYX@Z@BX@OIGEVL _J@NGOB P@EBDQ`@VCGBOCALMW@EB@OQDOaULDLDPGIGEVF@BGHDICAJCL@GL@LMbOGLPcLFWSECT@OLCBUF@VCAGIW@EB@OMdDBB@OVGPMYX@Z@BX@OIGEVL eJ@NGOB P@EBDQbEVDAOCEDIDKUGEVF@BGHDICLPMfPLB@OVGPSFWMSECT@OLCBUDQfPLB@OVGPMfPLB@OVGPMYX@Z@BX@OIGEVL gJ@NGOB P@EBDQhEB@OEGIF@VCACE@MdGVHDcVSECT@OLCBUF@VCAGIW@EB@OMZCiP@K@EMYX@Z@BX@OIGEVL jJ@NGOB P@EBDQ`@VCGBOCALMbPPGWXCIVO@E^L\DLNCBGIMfPLB@OVGPSFWMSECT@OLCBUDQfPLB@OVGPMfPLB@OVGPMYX@Z@BX@OIGEVL kJC TCLCDEDQF@BGHDICAJCL@GL@LMl@GBOCmWXCIVO@E^L\DLNCBGIMSECT@OLCBUF@VCAGIW@EB@ORODECEK@EMSECT@OLCBUDQRODECEK@EMRODECEK@EM YX@Z@BX@OIGEVL nJ@NGOB P@EBDQ`@VCGBOCALMfPLB@OVGPSFWMoOCi@SECT@OLCB@CBfPLB@OVGPMfPLB@OVGPMYX@Z@BX@OIGEVL pJ@NGOB P@EBDQhEB@OEGIF@VCACE@MW@EB@OQDOaULDLDPGIGEVF@BGHDICAJCL@GL@LMbOGLPcLFWSECT@OLCBUF@VCAGIW@EB@OMdDBB@OVGPM YX@Z@BX@OIGEVL >qJ@NGOB P@EBDQ`@VCGBOCALGEVWICECAGIR@E@BCALMFGGLBOCAXBSECT@OLCBUF@VCAGIW@EB@OMFGGLBOCAXBMYX@Z@BX@OIGEVL >>J@NGOB P@EBDQhEB@OEGIF@VCACE@MJCTCLCDEDQbEVDAOCEDIDKUGEVF@BGHDICAJCL@GL@MFGGLBOCAXBSECT@OLCBUF@VCAGIW@EB@OMFGGLBOCAXBM YX@Z@BX@OIGEVL >[J@NGOB P@EBDQ`@VCGBOCALMdGVHDcVSECT@OLCBUF@VCAGIW@EB@OMZCiP@K@EMYX@Z@BX@OIGEVL 8

(29)

(30)   . 5

(31)  `@B@OFrTGE\GLL@IBGEV\GEE@s@fr \GCi@LM]CIX@IPCEGWXCIVO@E^L\DLNCBGIM bTCV@EA@QDO@QQ@ABCT@E@LLDQE@vHDOELAO@@ECEKwZl?xQDONODNCDECAGACV@PCG SECT@OLCBUF@VCAGIW@EB@OSBO@AXBM w`fxGEVCLDIGB@VP@BXUIPGIDECAGACV@PCGwFFfxCLLAGOA@r`OCDOBDCPNI@y acEVIGGEjM_gnebfSBO@AXBMBX@ P@EBGBCDECEBX@Z@BX@OIGEVLMv@GCPBD@LBCPGB@BX@@mN@AB@VX@GIBXKGCEDQ Z@BX@OIGEVLr bPGCItNrTGEXGLL@IBucPAcBO@AXBrEI Zl?QDO`fGEVFFfrhEBXCLEGBCDEGIO@BODLN@ABCT@ADXDOBLBcVUMBX@AICECAGI 5

(32)   !fFJMGAcB@P@BGHDICAV@ADPN@ELGBCDEzf{MGVT@OL@DcBADP@zlFJMHDE@PCE@OGIV@ELCBUzb{M@GOIUDEL@Bza{MIGB@DEL@BzFFfM P@BXUIPGIDECAGACV@PCGzZl?ME@vHDOELAO@@ECEKz`fMNODNCDECAGACV@PCGz`|MNGBC@EBU@GOz]\{M]DOIV\@GIBX{OKGECLGBCDEr \GEE@s@fr\GCi@LGEV}@Ps@FDI@PGADEBOCHcB@V@~cGIIUBDBXCLLBcVUzFDEC~c@]CIICGPLGEV`@B@OFrTGE\GLL@IBADEBOCHcB@V@~cGIIUBDBXCLLBcVUr YXCLCLGEDN@EGAA@LLGOBCAI@cEV@OBX@B@OPLDQBX@WO@GBCT@WDPPDELfBBOCHcBCDEyZDEWDPP@OACGIaCA@EL@MvXCAXN@OPCBLcL@MVCLBOCHcBCDEGEVO@NODVcABCDECEGEU P@VCcPMNODTCV@VBX@DOCKCEGIvDOsCLNODN@OIUACB@VGEVCLEDBcL@VQDOADPP@OACGINcONDL@Lr €[q>pYX@fcBXDOLr‚ƒ„ †‡‚ˆ‰ Š‹„Œ‹Ž‹†‚‡Œ‘’Œ“‹†“‹NcHICLX@VHU”DXE]CI@U•?DELaBVDEH@XGIQDQ??hbF 0+0 vCI@UDEICE@ICHOGOUrADPiDcOEGIiCPV ‰ Š‹„Œ‹†’Œ“–[q[qze_te[e—e_kr.

(33) 5X< 0 I\2. 0123242526789. 7

(34) 272

(35)   28 0522526 !"#$%&#'()*+ 5*,, 788 -&$ .'"#  /7890 780

(36) 891)782 3794 54*7

(37) 75 6 0*,3

(38)  77. `ab. **,892:;1789337

(39) 819

(40) 7+8*9538<787= >?8?789< =@A>?13747 792B

(41) 4

(42) 8

(43) 7 ** 77 3 9,

(44) 89794** *,,

(45) = * 7

(46) 71,C8=*,7 75*

(47) 9* 87

(48) *803;61*+8

(49) 

(50) 4,8

(51) *81

(52) **89

(53) 7 * 

(54)  7

(55) *817897 8 79* 

(56) 7

(57) *82D* *,7

(58) 8

(59) 98

(60) ,

(61) 9 5=,7

(62) =

(63) 8+3* 793

(64) ** *,

(65) 

(66) 89/

(67) 5

(68) 8+28 794** 9*,

(69) = * 7

(70) 737*99

(71) 8E9F*, 

(72) 8

(73) 7 =9

(74) 7+8*97

(75) 82D* *,,

(76) = * 7

(77) 737 

(78)

(79) 7

(80) 8G2?

(81) 5

(82) 8+7

(83) 7895

(84) 8E2?7

(85) 2H79*897=*,9

(86) 7+8* 

(87) *,

(88) 8

(89) 7 =9

(90) 7+8*97

(91) 8789

(92) 5

(93) 8+7

(94) 787 =

(95) 17

(96)

(97) 87= 

(98) 799

(99) *8*,794** 9*,

(100) = * 7

(101) 7 ,* E9F*9F:F377  792 *8+

(102) 5

(103) 8+7

(104) 13;,C8=1 *+8

(105) 

(106) 4,8

(107) *81

(108) **89

(109) 7 17897 8 79* 

(110) 7

(111) *83 * 775 2I ++77 +7

(112) 8*,4H0,*178933

(113) 8*47 **  7=5

(114)

(115) 917*8 =7 *997*,794* * 9*,

(116) = * 7

(117) 7

(118) /92J

(119) 8

(120) 8

(121) 7 7

(122) 18*993;,C8=1

(123) *49*+8

(124) 

(125) 4,8

(126) *81*99 ,C8=*,

(127) **89

(128) 7 *7 8 79* 

(129) 7

(130) *8785/92 K%LM NOPQ = 7 *8

(131) 7

(132) 9

(133) 713314H01835*88

(134) 8+111*

(135) *8

(136) 7

(137) 9

(138) 7. R S TUVONPWVTNU. 1*

(139) *8

(140) 7

(141) 9

(142) 7011D3X3 Y9A9AAGE6789

(143) * 79 = 7 *8

(144)  7

(145) 9

(146) 7 0331 D3X3 Y@G>AAA1 Y@G>>AA1Y@G>>>A1Y@88EAA1789Y@88E>A67795= 8Z= 789*,7*9,

(147) 

(148) 8

(149) 

(150) 84* 49

(151) 8*

(152) *8=  [*5779*382I

(153) 8

(154) 7 *7 =73

(155)  787 75*

(156) 9* 87

(157) *803;6

(158) 88*87 7 >

(159) *907 =*81 D6*7,0 7*81 \D62I,

(160) = * 7

(161) 7,C8 =7

(162)  4

(163) 5 8* *+

(164) 7 97 7+1 78

(165) ,

(166) 8+7 *4 8 9

(167) *9

(168) 847=

(169) 8+4

(170) =7892*=* **797 

(171) *82I

(172) 8* *+

(173) 7 97 7+

(174) *,8, 95=3

(175)  7 

(176) *87892*577 +78+

(177) 7=

(178) 88

(179) 

(180) *8 57

(181) 8

(182) 7+

(183) 8+2X8 799

(184) 

(185) *81 

(186) 8

(187) 7 *

(188)  77

(189) 95=,C8@3;1*+8

(190) 

(191) 49,

(192) 

(193) 1789 *8+ * 

(194) 7

(195) *82 9

(196) 7+8*

(197) 5,*,

(198) = * 7

(199) 71,7

(200)  5 *+835*88

(201) 8+04H0 61* 9*

(202) 7 =  488* *+

(203) 7 97 7+25*341 7]*

(204) = *,7

(205) 8

(206) = * 7

(207) 3 5,*4H0  785 747

(208) 75 1

(209)

(210) 

(211) 8+*8

(212) 7 +7

(213) 82E1G B*9

(214)  9

(215) 59*8

(216) 7 799

(217) 

(218) *87 47 *,4H0 157 9  ? 3

(219) 

(220)

(221) 97  

(222) Z789,* *3

(223) 1  

(224) 8+

(225) 8*8*4=75**8

(226) 7 ,,

(227) 48*,4H0 ,*1789332. 378=,,*7458 79*7

(228) 4*88 *83

(229) 9

(230) 77

(231) 75 ,*8

(232) 8+15**87 + *57 >A 1>4> 5=  J* 9 57  D+78

(233) 7

(234) *8 0J5D6 00  87=4*0>6789*8 *78 4 2>@>E;

(235) ,,*1

(236) 

(237) 

(238) 95775 3

(239)  9

(240) 7*8,*789

(241) 

(242) 8* 7*837

(243) 

(244) 7 9

(245) 

(246) *8* 955791 

(247) 8+

(248) 89

(249) 4+8*8  

(250) *82^+79

(251) 8+17893314H0

(252)   87

(253) *87>G 58* 899

(254) 8_8

(255) 907*, 

(256) 71 517893338*

(257) 8 99

(258) 8 *78

(259) > *,@99

(260) *9*5*8

(261) 99,*4H0/78

(262) *82 44 147  *78*8

(263) 

(264)   89 4H0,*1789332G X84 789157 [*8

(265) 9

(266) 99579 *8/97 +7

(267) 8,*\D7

(268) 874H0,* 178933  8

(269) 8+

(270) 

(271) 77893

(272) 7

(273) 8 D*5@A>?2>9 4H0 3

(274) 5 ,* 9 579 *8

(275) 879[78

(276) 

(277) 8789

(278) 879[2[@78

(279) 

(280) 8 7

(281) *1*   893

(282) 7*89

(283) *8

(284) 879 @ = 

(285) 

(286) 7

(287) 9789 = 7 *8

(288) 7

(289) 92 

(290) 7

(291) ,* 93

(292) 

(293) 8897=7,5

(294) 17

(295)

(296)  **7*

(297) 

(298) 4*89

(299) 3

(300) 

(301) 8>>@>97= 7,5

(302) 2 B*799

(303) 

(304) *8*,839

(305) 7*4H01J5D 

(306) 

(307) 7 *,7

(308)  7

(309) *78 7 =9,

(310) 89 *5]

(311) 40J5DY@614

(312) 98,*,,

(313) 480J5DYE6.

(314) k1n. 0123045678590870

(315) 1  78551 04

(316) 5 

(317) 20 56

(318) 4012  !55 !45534 54 0045 1

(319) 766 3 51 85 8

(320) 25 5 0 551  !0 "

(321)

(322) 2 8

(323) 1"# 54

(324) 7 3

(325) 5  !578 0 5"

(326) 08012 !0 

(327) 1

(328) 4# 1" 153504

(329) 590870 5$4

(330) "4058

(331) 1"# 54%

(332) 7 3

(333) 5 40458

(334) 1

(335) 452 10 012042 5201154 5546

(336) 452010

(337) 10845 4

(338) 53 953

(339) !

(340) 4  72 13872 1"&'()%*7 3!012 0 51 50 

(341) 256 15+! 3!

(342) ,-53 953

(343) 782,50. 0 152+ ! $ 8551 0

(344) 1545

(345) +55 0 5 !55.53 52!508 ! "0 1 1 !55 !548012,3

(346) 04 1" ,8 1"2 0"1

(347) 52 9 060 8 5 1"+ ! !5 4

(348) 8254 125. ,8 1"/1022 #.

(349) 1+55.8

(350) 45!

(351) +590870

(352) 1

(353) 6$ 8551 0

(354) 1 301,5546

(355) 452,05 1"15+8256 15238 1 308

(356) 7 # 3

(357) 50405 5400 8+575 1 "! 

(358) , 0 15264

(359)   72 1" ! 45#$3

(360) !

(361) 4.

(362) "7 253

(363) 71588 1"012 7495 880135

(364) 6$3

(365) !

(366) 4 . 1 2 3456789 1:; 2 <=>?@A>?ABCDE?FA=AGBFHIC?=AB@ J?>K@>K?BELD?G@C?A@E. /1 ! 10

(367) 1+ 2545 4

(368) 53 953

(369) !

(370) 4  720 51 M 38 1 308453

(371) 4264

(372) 088 .*7 3!5 0,

(373) 8 3351 45+545 0108520 51 +54558 " ,856

(374) 4 1387

(375) 1 6

(376) 4 +03

(377) 16 452,51N0 303 9 0108 

(378) 4 7 0

(379) 1 0108 

(380) 6OPPQOPPRSTUSSQQ SSQRSPVV

(381) 4SSQWXP0 51 

(382) 4 !5 485"08 "7042 01 "15201 16

(383) 4523

(384) 151 6

(385) 404

(386) 9 1" 0108 

(387) 6 !5 438 1 308453

(388) 420127,8 30

(389) 1

(390) 6 !5 01

(391) 1

(392) 720 0 10"45551 + ! 1. 7

(393) 108012 10

(394) 10885" 80

(395) 1!5 72+004

(396) 952, !5Y ! # 308Z

(397) . 55

(398) 6 !5 [1 954  52 308Z51 54 [ 453! &#\](Z012^

(399). 5420 YZ#_])#%_

(400) 1 ,5!086

(401) 6088Y ! 308Z

(402) . 55

(403) 6 19

(404) 8952[1 954  52 308Z51 54884

(405) 3527456

(406) 88

(407) +52+545 1033

(408) 4# 20135+ ! !55 ! 308 012042

(409) 6 !553

(410) . 55012 + ! !558 1` *538040

(411) 1

(412) 6&a0459 52 1_]]]. 1:1 2 8=>=BFCC@B>?FA. *0 03

(413) 8853

(414) 1+0546

(415) 452, +

(416) 195 "0

(417) 4  012b *0 0+5455. 403 5264

(418)  ,

(419) !054012 5853 4

(420) 1 30 51 6 85*0 0+5453

(421) 8853 5264

(422)  !56 4. 

(423) 0 3!0571 8 !580 6

(424) 88

(425) +#79  *0 03

(426) 8# 853

(427) 1+06

(428) 3752

(429) 10 51 01260 83!0403 54  3

(430) 7 3

(431) 5

(432) 6 !56 4 

(433) 0 3!05 *!

(434)  08 02 

(435) 13

(436) "1 950123!

(437) 

(438)

(439) 425958

(440) 51 012 8

(441) 1"# 54 3

(442) 8 30

(443) 18820 0+54551 5452 1 !5 51Z8 1 30

(444) 51

(445) 7435

(446) 6 +045954

(447) 1%__. /oYY0. Y +0256 1520015 

(448) 25

(449) 65954584527352 38 1 3083

(450) 12

(451) 1 04 1" 1 !56 4 _)20

(452) 68 65012  00

(453)  04 1"06 54_)20

(454) 68 65 0 51  251 6 52 !4

(455) 7"!60 8 5 1",052

(456) 10106653 52

(457) 8254 125. ,8 1"+54545"0425205040 530 5"

(458) 4. 1:c 2 7D>BFH@I=d=H@>@dE. 

(459) 590870 538 1 308

(460) 7 3

(461) 56 95"4

(462) 752

(463) 7 3

(464) 5 0405 54+545 256 152 78551 04 

(465) 5_ e29545

(466) 7 3

(467) 5 

(468) 6 !56 4 

(469) 0 3!05f +030 5"

(470) 4 52,052

(471) 1 !5455135

(472) 6

(473) 9551 2 #

(474) 4254 !0 25958

(475) 52274 1"

(476) 44 "! 06 54 !56 4 #.

(477) 0 3!05

(478) ,-53 6 52274 1"6

(479) 88

(480) +#75.0 10

(481) 1 ,052 0 4 31574

(482) 8

(483) "  012!

(484) !540  !

(485) 4 8 06 54 !56 4 

(486) 0 3!05012(

(487) 4 !5455135

(488) 6 ,008"01"8 0!54 1 51 5

(489) 4+! 50. 540,1

(490) 408 #. 525 53 520. !56 4. 5

(491) 6,40 1 0" 1"06 54 !5 6 4 

(492) 0 3 !05 78551 04 

(493) 5 _ e *645g7513f+0256 152,052

(494) 1 !5645g7513

(495) 6 512 1" * 45g7 4 1" !

(496)  0802 

(497) 1 54 0 51 504 h 1 !56 4 \504

(498) 68 65

(499) !54 !01 !5 6 4 

(500) 0 3!05 78551 04

(501) 5_eZ

(502) "# 1 956713

(503) 1f+02  1"7 !52 1 !45530 5"

(504) 4 5 ,052

(505) 11574

(506) 3!

(507) 8

(508) " 308 5 4578 

(509) 4 1 !50,5135

(510) 61574

(511) 3!

(512) 8

(513) " 308 5 4 578 

(514) 152730

(515) 10885958

(516) 4 4

(517) 65

(518) 10858

(519) 51 & 78551 04

(520) 5_ 0

(521) 1"# 543

(522) 8 30

(523) 1+5452 9 252 1

(524) 

(525) 3!

(526) 124 08. 450 51 #4580 52 012  3588015

(527) 7 3

(528) 8 30

(529) 1 0 51 +54530 5"

(530) 4 52 1

(531)  .30 5"

(532) 4 5,052

(533) 1 !5 17,54

(534) 6

(535) 3!

(536) 124 083

(537) 8 30

(538) 14551 0 0354#. 0 1 0"5!55

(539) 3!

(540) 124 083

(541) 8 30

(542) 1 1387252 _3_

(543) 8 30

(544) 18 `58

(545) ,530752,

(546) 3!

(547) 124 0860 8# 745 78551 04

(548) 5_Z

(549) 8 30

(550) 1+ !

(551) 51#. 08 450 51 #4580 5205

(552) 8

(553) " 138725225345052,

(554) 15_  15408251  $ *"4

(555) + !45 0420

(556) 1012

(557) ,5  78551 04

(558) 5_i4

(559) + !45 0420

(560) 1+0256 152 4551 +!51!5 "!.

(561) +5 "! +085 !01j_*0 01 

(562) 51 274 1"6

(563) 88

(564) +#7 !543

(565) 8 30

(566) 1+ !1

(567) 59 251356

(568) 40

(569) 85

(570) 3!

(571) 124 08

(572) 4 450 51 #4580 52 05

(573) 8

(574) "+545 45"04252  3588015

(575) 7 3

(576) 8 30

(577) 1 !553

(578) 8 30

(579) 1 13872525801

(580) 908"7

(581) 4 #0_#30 ! 1653

(582) 1 55 !5105825653 74

(583) 8 ! 0 012"

(584) 7 . 1:k 2 8=>=l=A=CmE?E. Y03!

(585) 7 3

(586) 50405 54+0590870 52 1 !53

(587) 85 5 3

(588) !

(589) 4 5040 56

(590) 4,

(591) !012 0 51 0125# 040 56

(592) 4,

(593) !Y01200 51 /1022

(594) 16

(595) 4088  *0"50 253

(596) 510

(597) 102 

(598) 12740

(599) 11552 6

(600) 4 1 51 95304571 02 

(601) 1012 * 4 ""54.

(602) uPGQQR9. _vw. 01211345647189 214

(603)

(604) 5

(605) 47 41182134 51

(606) 104

(607) 45

(608) 6547189 42  27 1 71745 1457 4 45531

(609) 5

(610) 45 67

(611) 142417120121

(612) 4218 17011 47178171845717487 1281 59 111

(613) 718 1457 404

(614) 45

(615) 6547181724  5478 7 15

(616) 42   7 127 7 47

(617)  417 7 11721

(618) 270 658 431115117189 45

(619) 6547 012112 218 2  51847 478173121657

(620) 6581

(621) 1 4345451!84"#$%%%&48'%471227 9 117 2(4

(622) 7 2 214

(623) 67

(624) 14241 7120412 218

(625) 42814171 2 7 )48**211747 7148 2**374 %'21 3119 557477

(626) 454451012112 218+2 24 546419+165742112118417 1214 2 18407 74842881347 48241 2,647 7473184744846124812

(627) 1741 2,64574731 8474976817-.717012112 218 2,64774731 847448  12-14

(628) 7717 2,6457473184749/34561 012148067184

(629)

(630) 287 7 1 122 17 80 1 657517170412 2184806718/3456119"& 0121

(631) 812187477

(632) 455

(633) 479/34561 515 21 27187 1717 27 14117 2(4

(634) 7 2 .

(635) 5

(636) 45 67

(637) 142417120121

(638) 45

(639) 6547186   12-14

(640) 7717480121 748067184 65751717 0412 2189. 2 3 4567896 2:; 3 <=>?@A>BC=D=B>@D?E>?BE. 455F#)48**47177 117 1254884  1817011G4642%H$H48G65'"%H$I4717 0121

(641) 568189 314717216187 427

(642) 47148

(643) 5

(644) 4521

(645) 28 70 81

(646) 1418**4717

(647) 658 7 1217213189 214254554717847401214345451 2  7 1277 47

(648)  417 7 1547 17   55 069 1

(649) 27

(650) 56818#%) 47172  'J45148 J&** 47172  J"4519 17011%G4642%HHF48#%K1

(651) 112'"%$JIL$I 4717M)!N%H**!N'$O012184 1807 4184 '47171227 142M241!%&O9P7  12 8#$'H%'F53127 012121712182 384 174718

(652) 81

(653) 17 117 12548 %!F%""" 2 )48**

(654) 18%!%HI""" 2)48%!%#F"""  2**9)211747 7104Q'HR#J4 5717%'486( 0%4717M451%O9. 9ST85; 4151

(655) 424

(656) 7127

(657)  7 1K67

(658)

(659) 27 )48**4717 )211747 71 )211747 41 e1 71 Ql14

(660) 737 m74%'21 311 147547 55 06 * 27457. <DUV?UA?B=B?W@X?=YAZ2;[ Q425 17 N%&aJFb R471 17 NFa'Ib. 45717 N$a'#b c( 0 N%a#b Q425 17 I9"&dI9%'84 R471 17 %J9%d''9H142. 45717 "9"$d"9%H142 /ffg NFa'Ib /ffk N$a'#b  6747 445N%Ia&'b "9""9J 5L L N%"a#'b "9&'9" 5L L N&a%Ib  7146218 N%Ia&'b. %H9'd%&9%142 N$a'#bMJQ%R'45O. \@>C]^X=^UA?B=B?W@X?=YAZ_`[ Q425 17 N%Ja#%b R471 17 N'Ia&Ib. 45717 N&a%%b Q425 17 '9"$d%9$$84 R471 17 %9J%d'9$J142. 45717 "9#'d"9$'142 hij N'Ia&Fb hhgg NFa%Fb hhgk N$a%Ib  6747 445NJaHb +1 31  721 31. N'%aJ$b N'Ja&#b %$9#d%'9%142 N'aJbM%R%45O. no.pq!Q425 17!211747 r'F84 519R471 17!211747 s'F84 519t6457473184744211211846124812

(661) 1741 ,647747318474414dK9 21347 !Q1425 17a4545717aR5471 179.

(662) ]=c. 0123245165758992

(663) 21235253683 728536 7  2123523  5 52151 982123 48528351 8 572 3726 37292 6 78 9521!7 72348 16387 485 6277 2 236 "2123 45  62451 486897 236 "2# 123  3875 52151   7572835351!255 52151 23$%&'(572 37536  51 6%) 28 1! 3 87 6 7572832341623 ' 75728323*++,$23*++-.23/01%23//,, 536%23//,-51 %

(664)  3534!5366 12 !  34812457 6237 52827!897 572 37387  427 2789 572 3752329245371!18  485 678

(665) 572 3723123 27 28  87# 51 56387572 377 927!7857245 545547 2 6!1 75!536538 "252329245371! 8 78 572 37  37 6 27 82723

(666) 155 5832557  375728352329245371!2 2398 572 37 172323 2329245371!8 98 572 37  : 2236251!251 ). ;<= > ?@ABCDBEFGHEIBEJGKBJLCDG DMINGEIOGLHNKODB. 3 8 897 927!7857245 5 486 623 5(&'()'P89511572 37536235Q&())'P897 41232# 4511!62538 6572 37R2 8  376286     486 623 %)&5(572 37455153125! # 237 3272   8  623.27 577 53851272  23)5368723(572 3763&%(572 37238 27 577 53851272 536&855153125! # 237 3272   8  652325235 98 6 2723565!78(837597 7 927!7857245 53623'&%(572 37157 23129 53 S83778 %5! 5637 897  572 3751858  37628# 6 5 486 653623511 3572 377 8  6 53851272   48326  678 183# "27 375 683 3453 641232451!78536252345547 2724 6398572 3753 86 787 927!785724 5 5 27 5 3788 897 3216  523 78572 3787897 338 86 787 927!78# 57245 5 486 66953 85 486 62378 572 37275 27 2168  242   3# 7 6!52329245376299  34 23216 86 787 927 !7857245 2398 78572 3751 %536 R2  86 787 927!7857245 7 36 6 78 1 9 : 3723572 3726 37292 678 9521! 7 723753237 22123 77 8 748 897 927 !7857245 23)&212352221523$&# 51 !78823  376 237 927 !7857245 38  3757283 7! 23

(667) 8  38 275234% 832 3 23 5 584257 62753234 5 62T9853 851 $. [ 6d99 7.  " 47 6 51752389U498

(668) 536 23 7 U 7 15365 7257 65 6837 8 3789   3757283895119853678572 3723724887536 5 6835351!289212352R2 51 536 51 5 8 724511!7 512 U4 175 5 521# 51 7 8 572 374816 87 47 698 53 8 6 787 927!7857245 R2 53651 5 63724887U4 175 52151 5765!Q89129 4816 5  37 653 823)572 37 6 4237  # 4 375 8953 86 237 927!7857245 98 )(P78%5PU4 175 52151  7 365!536 %48165  37 653 823(8$572 37 6 423 7  4 375 98)(P785(P#5.P51 5. ;<; > ?VWJCBXFBYHM. 6378751(% Z  : 22382751562283   87 6[82751257283 6 57283 5 2329245371! 87 23 75323

(669) 572 37 Z72   2215277 "4 7283892329245371!8 9 : 37 9 62381 23 572 37536483725728323

(670) 572 3751 ( 837 212352 Z9 : 34!52215 23)&52 236 "572 3789)&21235262 6 981182353 Z  5511 783 897 2123 26 37292 678 9521!7 7235 7211512 5178  4 371!831!

(671) (5 2 622123235 51  Z 9 : 34!7 36 678 297 6785658   9 : 34!2398572 37485 67878572 37 51 %536R2 4 7 3

(672) 536 572 37 386299  34 23 Z9 : 34!5 486 651 ( 83

(673) 572 3798 572 37 " 2 34 623292# 45371!8 Z&

(674) \ * QQ%536583 572 37 275234% 3 832 572 37 " 2 34 6 2329245371!8 Z&

(675) \51 (. ;<] > ^E_YLGLABJFYHGLEY. 78751895 3 8!481824517 7 17   486 623)(&'(572 37275 6253897 7 7  572 3753 S#Q63'572 37483272 934# 728355 6837 572 373 6 457283511 153623 5572 37483272 934728353875  6! 7 3 6` aQ5387 623%)&(5572 37536`  7 3 (Q536Q23%Q&(5572 37536536` b(Q23&(5 572 3751 ' 083272 9347283548551 5837 2# 123522215235 77 23%8 23387 5  623551 5 115 7 39853678 572 3751 %536R2   36`b(Q523292# 45371!8  51 3723

(676) 572 3751 ' 83.

(677) œ1 › “1 %. yj| vwÿ tÿujk ÿHI. eftghÿ ÿujk ÿGI. lmnmtomÿuÿjk ÿÿÿI tpm ÿuqÿÿrÿsG. y€| vwÿ tÿujk ÿÿÿK eftghÿ ÿujk ÿÿÿK. žŸ . cddS __UVÿXYZ[\]]^ RRSS Rab TUVÿXYZ[\]]^ Rab TUVÿXYZ[\]]^ Rab RRSS cdd` cdd` cddS TUVÿXYZ[\]]^ RRSS RRS` Rab __UVÿXYZ[\]]^ cdd` Rab Rab TUVÿXYZ[\]]^ TUVÿXYZ[\]]^ TUVÿXYZ[\]]^ cddS Rab TUVÿXYZ[\]]^ Rab cdd` cddS cddS Rab TUVÿXYZ[\]]^ RRSS cddS Rab RRSS Rab TUVÿXYZ[\]]^ cdd` Rab RRS` __UVÿXYZ[\]]^ TUVÿXYZ[\]]^ RRSS. cddS __UVÿXYZ[\]]^ cdd` cdd` TUVÿXYZ[\]]^ RRS` TUVÿXYZ[\]]^ TUVÿXYZ[\]]^ Rab Rab Rab TUVÿXYZ[\]]^. qogzÿw{mrÿqhÿgqrmÿw{mr. U‚ƒÿ\„ÿˆ‰ƒ]ƒY„\„†‡Y U‚ƒÿ\„ÿ †\‚Y‡]†] U‚ƒÿ\„ÿ †\‚Y‡]†]ÿXYŠY‡‹Y. tÿuÿG tÿuÿH ttÿÿuuÿÿHJ tÿuÿN. tÿuÿI. E F G H I J K L M NFEFFFGFHFIFJFKFLFMFNGEGFGGGHGIGJGKGLOPQ jxmÿyhqz{| }q~fgzÿrm{rfx. E F G H I J K L M NFEFFFGFHFIFJFKFLFMFNGEGFGGGHGIGJGKGLOPQ jxmÿyhqz{|. ŒŽ‘’ 1 6347864373 63453 7858*2*2575356(5301'37(64(375356(53))1'23456748%1903456748.

(678) 5463**34678642*686743457%+90345674856745564* 3(5468457 %“63”586254846234567489*6*6742636*86 4(69373 63453 7858%“6”3”58625484623456743 657389

(679) 543(3”5((&•3863*7864'% 5 4 *65*686254 3 6342*68674345793*– *65*6862543 63453 785892675*68625457

(680) 523456748466”343 63453 7858587–7

(681) 7%—* 33 68342*686743457373 683453 7858˜&•383 63467864'9465*6836™66723634&•38%“66*453*6855768 6254462467453((6748š+›*6848™6(63353™6957576

(682) 54“3™6"% 7466446866*5436*864(68 1 '64465*848(24(34523863*65846736*864(69(59866*69*63464465*848(24(3452386. 01234567489

(683) 3885 7553743885346

(684) 54 75 4567457  9 !"9#$ %&'% 1(7 ))1 2345674892*6867434574267*543(57 +,& *68278567688

(685) 6*6 3885346

(686) 54  75456 7457%. -./ 0 12345678962:;<69=429>:9685 36927=2:?@6858>96252AB. )547*53(2534578

(687) 6*6 2*6867457 CDC! 23456748937

(688) 6*6(557"9(6*34657,"9866*657.

(689) FEU. l^meef. 123456 78 757 383778 385 4& 87 743 49 7 5678 77 8  9 3  3 7 M35678 77 $ 535678 77 7678735678 77 W7357 8  87 743 4 $W87#749 M47X4$W 4 8 

(690) 9738. $ 5XY,,Z,*$W+[ $57837XY,*Z0,$W+[ 76787XY0,Z1,$W+[ \789 76787XY1,$W+[ W73X58 4&857$W M ]&4  674 4 78 0X^_YS,887&38753 4 78 1X^_.,S,8 7 3753 4 78 PX^_-.,84753 4 M $ 458 3  3 4. M47 $ 5 $57837 76787 \789 76787 W73 M 8737487375  3 4. M47 $ 5 76787 \789 76787 M. 589:;<=>?@ A=B6CD. 48@?<=>?@ A=BEFD. GH8:I?. 3<=J?99<=K L<99?L@K<=. 4N00OPQR 4N0O*SR 4N,O,R 4N0OPR. 4N1PO.

(691) R 4N.O10R 4N

(692) O01R 4N0OPR. ,1

(693) ,,0 00Q 0,,,. M TUUV M M. 4NPO0,R 4N0OPR 4N1OR 4N.O10R 4N00OPQR 4NPO0,R 4NPO0,R. 4N0POPQR 4NPOSR 4N1O.R 4NPOSR 4N*O0*R 4N0OPR 4N O10R. ,0S .0Q 0,,, 1Q, ,

(694) * P1. P0S. M M M M M M M. 4N

(695) O0

(696) R 4N0,OP

(697) R 4N0,OP

(698) R 4N*O0R. 4N0*O

(699)

(700) R 4NQO1

(701) R 4N*O0*R 4N.O0QR. ,0P 

(702) , ,Q0 0,,,. M M M M. 4N0OPR 4N.O10R 4N*O0R 4NSOP0R 4NQO1QR 4N,O,R 4N,O,R. 4N*O0*R 4N0SO*.R 4N*O0*R 4N1O.R 4NPOSR 4N,O,R 4N,O,R. 1,* ,,* 0,,, ,0 ,SP 0,,, 0,,,. M TUEF M M M M M. 4NSOP0R 4N0,OP

(703) R 4N.O10R 4N

(704) O0

(705) R 4N,O,R. 4N0O*,R 4N0POPQR 4NPOSR 4N0OPR 4N,O,R. 0SS SQ 1Q, 00 0,,,. M M M M M. `abcdX5678 77 8  9 3  3 7X5678 777 8  9 3  3 7e3894 7X 87 743 4Z1Q539  7Of374 7X 87 743 4Y1Q539  73  3 &4  3473 5778 4759" 78g 7h37  i637 78735j 75385 4&7k47884 75 5j 75i637 -,*7874 57875 3  39 &4  3434538757 75 45 876 3 4 X$W23773 57 74 3 4OM243. 7. 75OM24 &4  34O[2 3 749738. 0123456789 76787 40

(706) 3 74 47 3 74  6789 76787 458 3  3 4 5 755738 5 9 398763747 458 3  3 4. 3  3875 7 7831873453 3 89 3 8378   3 4 37!"8# 7 7   3 4 27 7 398$$2 87637473 787 3. 7. 7587 8  7 438 5937!. %7433 873. &4  34987 87637434& $$ 3 74 3434& 3 74 37! "8 458 3  3 4  374 72 3&734 73 3. 7. 7537 345" &871!7 738 7 34 7 3 4 87433 87 3 387359 87 875373&7019738 434''() 3 74345 4*+1, 3 74 3&74 73 -.9738 1'/02.

(707) *./0 12"3 ?@@A:B?; =KL>K. EDA:FF; =K>KJ DBA:NC; @A:@; OKP>

(708) K @A:@; OK6>

(709) K9 @A:@; ?@@A:M; ??A:?; CMA:C; EBA:E; DDA:D; XZ E@A Y[. \?D Z:]

(710) ; ] ^ NFA_?D. +&%,'-. *.50 12"3 CDA:E?; EMA:F@; D?A:N?; ?BA:?@; F@A:F; G@A:G; ?@@A:M; ??A:?; CMA:C; EBA:E; DDA:D; E@A \?? NCA\?G. *.40 12"3 B?A:FG; BEA:ND; FEA:?F; FMA:ND; FCA:M; BNA:?E; ?@@A:M; ??A:?; CMA:C; EBA:E; DDA:D; E@A \G FDA\N?. *.550 12"3 EBA:FD; BCA:NF; FNA:??; DDA:NG; FGA:?@; BFA:?G; ?@@A:M; ??A:?; CMA:C; EBA:E; DDA:D; E@A \B FBA\NN. *.560 12"3 EDA:FF; G@A:NF; F@A:?@; DBA:NC; FBA:?@; BDA:?C; ?@@A:M; ??A:?; CMA:C; EBA:E; DDA:D; E@A \E FCA\NF. *.750 12"3 EDA:FF; G@A:NF; F@A:?@; DBA:NC; FBA:?@; BDA:?C; ?@@A:M; ??A:?; CMA:C; EBA:E; DDA:D; E@A \E FCA_NF. `abcde< J9 8 9  

(711) 9

(712) B?f97 

(713) 98 9 

(714) 9  9

(715) 9  9 9\?N>97 

(716) 98 9  g 997

(717) 

(718) 9Xg>\F:P99?;T<9  9 9 

(719) 9  9

(720)   9 9

(721) 9  9 989 9 99 8 > 9J9 8 9 g9 9>  9 989   9 T<9 

(722)   9g 989 9 99

(723) J9 8 9 g99.   9

(724) T<9 9 98 

(725)   9 9

(726)   9  

(727) J9 9J9g9g

(728) J9899 9

(729) T=89 9 99

(730) 8 9 J9g99

(731) 9

(732) T =JJ9 e=I>

(733) 99 9fQO>

(734) 9  9f>9gJ 999T. $%&'( <  H  =I H =I <  H  =I H =I <  H  =I H =I H  =I H =I. )* => >J L>. 8 9 

(735) 99

(736)  9  8   89 O>

(737) : 9899  ; 6>9 P> Q

(738) 97J9 8 9 

(739) 9  9

(740) 9  R>9 9 9 ST Q> J9

(741) 9  9

(742) 9  9 9 U>V W>X 6  9

(743) 9 9   Y 8 9 9

(744) =I: 9899  ;  89 9 99=I  8   89: 9899  ; >. !"# 8 9 

(745) 99

(746) 9: 9 899  ;. 012345 6789 9

(747) 9 9  899  . 9 9 

(748) 99 9

(749) 9  9  8   89. S=QU66<=YT h55.

(750) ‘‰. ’ 8“1)1 .. 011234567896 5

(751)

(752)  7 

(753) 56 

(754) 5 6  67 65 5

(755)

(756)  5  6 4567 5!"5

(757) 6## $57 5 6 5

(758) 67 5%&5

(759) 4 5588'5

(760) 6 45675 80"5

(761) 6## (5 )% 56

(762) 5* 5 4 

(763) 4567

(764) 6

(765)  695 5 6 

(766)

(767) 567  8+5

(768) 45

(769) 

(770)   5 6

(771)  5 5

(772)  5 656 57 

(773) 6 (5 )% 567, 90 #  67 5  5 6

(774)  55 56

(775)  65 

(776) (

(777)  5 684 6-4567

(778)  6- (5 )8./5 6

(779) 

(780) 6  56 096   7756  7  67 5  5 6

(781) 561/5 6

(782) (5 0567, 9)8 5 6

(783) 57

(784)   67 5  5 6

(785) 56 ofrÿsqltulmuvÿjvuwhxuj XGAM?GBC W?G;@EV?Q;MC N?<BE>A<?H>;MÿD?;>A<QÿMEBB U;>KAEVCEG;@DC :>EME<Q?KÿRS=ÿA<@?>T;M N@>EO?PMAO?ÿ?GABEK? JAK<?CÿL;AMH>? FG@A=HBÿ;@>EGDC :BC=DEBAB :;<=>?;@A@AB. ## 5 6

(786) (5 )%45675 

(787)  5 6

(788) 1/5 6

(789) (1/&!24./+2434+85 6 ## 5 6

(790) 4  67 5  5 6

(791)  5* 5 61/567./5 6

(792) 95 6  75

(793)   67 5  5 6

(794) 5

(795)

(796) 6  56   6 5 668096

(797) 6

(798) 5 6

(799) (96

(800) 6

(801) "!24

(802) 6

(803) 0-2434+8" 1/  567 5 668096

(804) 6

(805) 6

(806)

(807)  ## 5

(808) 967

(809) 6  56 5

(810)

(811)  57  5 

(812) 7  67 5  5 6

(813)  5 9 6

(814) (, 9!86577  641/ 6 6775

(815)

(816) *. 57 . 96 55 4 67  65 4

(817)  

(818) 

(819) 4567

(820) 6

(821)  695 5 6 

(822)

(823) (, 9)09 5 668096

(824) 6

(825) 6

(826)

(827) 677 5

(828)

(829)  57    . 96    54. }ÿ~ÿ` }ÿ~ÿZZ }ÿ~ÿ_ }ÿ~ÿ` }ÿ~ÿ` }ÿ~ÿ[ }ÿ~ÿZ }ÿ~ÿ] }ÿ~ÿ\ }ÿ~ÿZ Y Z [ \ ] ^ _ ` a bZYZZZ[Z\Z]Z^Z_Z`ZaZb[Y[Z[[[\[][^[_[`[a[b\Y\Z\[\\\]cde. oyrÿzhk{p|xj|lmuvÿjvuwhxuj W?G;@EV?Q;MC XGAM?GBC N?<BE>A<?H>;MÿD?;>A<QÿMEBB JAK<?CÿL;AMH>? :>EME<Q?KÿRS=ÿA<@?>T;M :;<=>?;@A@AB FG@A=HBÿ;@>EGDC U;>KAEVCEG;@DC :>?V;@H>?ÿET;>A;<ÿL;AMH>?. }ÿ~ÿZ] }ÿ~ÿ[ }ÿ~ÿ\ }ÿ~ÿ[Y }ÿ~ÿ] }ÿ~ÿ[ }ÿ~ÿ] }ÿ~ÿZ }ÿ~ÿZ Y Z [ \ ] ^ _ ` a bZYZZZ[Z\Z]Z^Z_Z`ZaZb[Y[Z[[[\[][^[_[`[a[b\Y\Z\[\\\]cde fghÿjkÿlmnhkÿophjqnr X;>MCÿE<B?@ €;@?ÿE<B?@ ;VAMCÿ@?B@A<Q A@;VA<ÿ‚Z[ÿ>?BGE<BAT? A@;VA<ÿ‚Z[ÿH<>?BGE<BAT?. ƒ„ †‡ˆ‰ 56

(830)   67 5  5 6

(831)  5 96

(832)  4Š 

(833)  6 5 7 5‹647 

(834)  5 6. 5 7 5*5Œ

(835) 7 

(836)   67 5  5 6

(837)  5 96

(838) 47767 56556

(839) Œ*5Œ

(840) 7 

(841) 5 6 5 65

(842) 4 55Π9!&5

(843) 5,5 5

(844) !&5

(845) 4  

(846) 56 5 75!&5

(847)  5 7 5 6

(848) 7 7 56556

(849)  7  

(850) 567 56 

(851) 7  67  795 5 6556

(852) 5  5 6$  

(853) 7 6  5 6680

(854) 6

(855) 6

(856)

(857) 4 56 

(858) 7  5 6680

(859) 6

(860) 6

(861)

(862)  5 6 5 7 55 6

(863) 6 9  

(864) 567 56 

(865) 7 5 6

(866) 46  

(867) 567 56 

(868) 7  56

(869) 456  

(870) 567 56 

(871) 7 7 56

(872)

(873) 95 

(874)  615  6

(875) Ž

(876) 65 60'75

(877)  ‹ 56

(878) Ž

(879) 65 60'75

(880)  .

Referenties

GERELATEERDE DOCUMENTEN

In deze openbare les en in dit boekje zal ik mij richten op de onderzoeksvragen die voortkomen uit de versmelting van de digitale en de fysieke wereld en de daarbij horende

La Prosperité is an old colonial timber plantation in the rural district of Para in Suriname, which was purchased by a group of former plantation workers after the abolition

Test-retest reliability and minimal detectable change scores for the timed “up &amp; go” test, the six-minute walk test, and gait speed in people with Alzheimer disease...

The church order is a rendition of the scripturo.l principles of church government and lS therefore founded On

Firstly, changes in expressions of parental warmth and harshness were explained by war-related stressors, such as economic stressors, unsafety, and emotional and behavioral

They serve as a niche for viral replication, vehicles for viral spread and contribute to severe disease development by sensing DENV and CHIKV infection leading to the production of

In summary, the techniques described here provide (a) a paradigm for responsible piloting with new security-critical technologies, providing more data on possible attacks and

Finally, corruption, environmental cost and environmental footprint, and human rights violations remain as negative effects of sports mega events to identify