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Macrophage regulatory mechanisms in atherosclerosis

The interplay of lipids and inflammation

Neele, A.E.

Publication date

2018

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Other version

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Citation for published version (APA):

Neele, A. E. (2018). Macrophage regulatory mechanisms in atherosclerosis: The interplay of

lipids and inflammation.

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Stellingen behorende bij het proefschrift:

Macrophage regulatory mechanisms in atherosclerosis: the interplay of lipids and inflammation

1. Het moduleren van macrofaagactivatie kan de uitkomst van atherosclerose verbeteren. – dit proefschrift

2. De H3K27 demethylase Kdm6b in myeloïde cellen is geen goed target voor atherosclerotische interventie. – dit proefschrift 3. Histon modificaties spelen een belangrijkere rol bij

macrofaag-activatie dan DNA methylatie. – dit proefschrift

4. Niet alleen macrofagen maar ook circulerende monocyten stapelen lipiden. – dit proefschrift

5. LDL verlaging door afvallen kan het pro-atherogene profiel van de monocyt verminderen.

6. Inflammatie speelt niet alleen bij muizen, maar ook bij mensen een rol in atherosclerose. – CANTOS, Ridker et al., NEJM, 2017 7. Single-cell transcriptome en CyTOF analyses zullen van groot

belang zijn om macrofaagactivatie in vivo te begrijpen. – Ginhoux et al., Nature Immunology, 2016

8. Stellingen zijn een makkelijke opening voor vragen tijdens de verdediging indien het proefschrift niet inhoudelijk gelezen is. 9. Nothing in life is to be feared, it is only to be understood. Now is

the time to understand more, so that we may fear less. – Marie Curie

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