University of Groningen
68Ga-PSMA PET-CT Imaging of Metastatic Adenoid Cystic Carcinoma
de Keizer, Bart; Krijger, Gerard C; Ververs, F Tessa; van Es, Robert J J; de Bree, Remco;
Willems, Stefan
Published in:
Nuclear medicine and molecular imaging
DOI:
10.1007/s13139-016-0445-6
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Publication date:
2017
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
de Keizer, B., Krijger, G. C., Ververs, F. T., van Es, R. J. J., de Bree, R., & Willems, S. (2017). 68Ga-PSMA
PET-CT Imaging of Metastatic Adenoid Cystic Carcinoma. Nuclear medicine and molecular imaging, 51(4),
360-361. https://doi.org/10.1007/s13139-016-0445-6
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INTERESTING IMAGE
ISSN (print) 1869-3482ISSN (online) 1869-3474
Bart de Keizer
1&Gerard C. Krijger
1&F. Tessa Ververs
2&Robert J. J. van Es
3&Remco de Bree
3&Stefan Willems
4Received: 28 April 2016 / Revised: 23 June 2016 / Accepted: 27 July 2016 / Published online: 16 August 2016 # The Author(s) 2016. This article is published with open access at Springerlink.com
Abstract A patient with a history of adenoid cystic
carci-noma of the nasal cavity presented himself with bone pain
and an elevated PSA level. On suspicion of metastatic
prostate cancer a
68Ga-PSMA PET-CT was performed.
The PET-CT showed numerous lung and non-sclerotic
bone metastasis. Biopsy of a bone metastasis was
per-formed and pathology showed adenoid cystic carcinoma
instead of prostate cancer. Immunohistochemical PSMA
staining of the primary tumour showed intense PSMA
ex-pression in adenoid cystic carcinoma tumour cells.
Because of the high PSMA expression of adenoid cystic
carcinoma,
68Ga-PSMA PET-CT might be a promising
im-aging modality for this malignancy.
Keywords Adenoid Cystic . Carcinoma . (68)Ga-PSMA .
Immunohistochemistry . PET-CT
Compliance with Ethical Standards
Conflict of interest Bart de Keizer, Gerard Krijger, Tessa Ververs, Robert van Es, Remco de Bree and Stefan Willems declare that they have no conflict of interest.
Fig. 1 Sagittal (a) and axial (b) fused PET-CT images and coronal maximum intensity projection of68GA-PSMA PET (c) showing intense P S M A b i n d i n g i n a d e n o i d c y s t i c c a r c i n o m a m e t a s t a s e s . Immunohistochemistry of the primary tumour showed intense PSMA expression mainly in adenoid cystic carcinoma tumour cells (d, arrows) * Bart de Keizer
b.dekeizer@umcutrecht.nl
1
Department of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
2
Department of clinical pharmacy, UMC Utrecht, Utrecht, Netherlands
3
Department of head and neck surgical oncology, UMC Utrecht, Utrecht, Netherlands
4 Department of pathology, UMC Utrecht, Utrecht, Netherlands
Nucl Med Mol Imaging (2017) 51:360–361 DOI 10.1007/s13139-016-0445-6
68
Ga-PSMA PET-CT Imaging of Metastatic Adenoid
Cystic Carcinoma
Ethical statement The study was approved by an institutional review board or equivalent and has been performed in accordance with the eth-ical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All subjects in the study gave written informed consent or the institutional review board waived the need to obtain informed consent.
Open Access This article is distributed under the terms of the Creative C o m m o n s A t t r i b u t i o n 4 . 0 I n t e r n a t i o n a l L i c e n s e ( h t t p : / / creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appro-priate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Nucl Med Mol Imaging (2017) 51:360–361 361
