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Plasmacytoid dendritic cells: how to control the good, the bad, and the ugly at
the molecular level
Karrich, J.J.
Publication date
2013
Link to publication
Citation for published version (APA):
Karrich, J. J. (2013). Plasmacytoid dendritic cells: how to control the good, the bad, and the
ugly at the molecular level.
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Claire once asked me what is it that I do at work exactly?
This was my answer, lets imagine a picture/slide of
a living immune cell including all the detailed molecular
processes (a lot of them) occurring in the cell in order
to keep it alive and then this picture is covered with millions
of playing cards so it is completely hidden like so you are
playing the MEMORY game. Well my job is to try and figure out
using various molecular biology techniques to be able
to turn over one or a few cards to see what it is hiding
and then publish what I discover in peer reviewed scientific
journals. However the major problem is I don’t believe that
anybody will ever be able to discover what all the cards are
hiding so that we can see the entire picture.
Plasmacytoid dendritic cells:
how to control the good, the bad,
and the ugly at the molecular level
ISBN: 978-94-6182-231-4
Printing of this thesis was supported by the Academic Medisch Centrum, University of Amsterdam, Amsterdam, The Netherlands.
Background cover:
http://4.bp.blogspot.com/- CcmJnc_NlFw/UFCo5OZL2xI/AAAAAAAABTM/ hqyIlMKSI6Q/s1600/western-hills-andsky-wall-inkbluesky.png
Back cover pictures, from top to bottom.
The good: Freshly isolated human plasmacytoid dendritic cells from blood. Magnification 20x (Leica).
The bad: Overnight activated human plasmacytoid dendritic cells with the TLR9 agonist CpG-B (10μg/mL). Magnification 20x (Leica).
The ugly: Leukemic plasmacytoid dendritic cell line CAL-1 isolated from a patient with CD4+CD56+ hematodermic neoplasm [Maeda et al., Int J Hematol. 2005;81(2):148-154.]. Magnification 20x (Leica).
Lay-out and printing: Off Page, www.offpage.nl
Copyright © 2012 by J.J. Karrich. All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
