• No results found

Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults

N/A
N/A
Protected

Academic year: 2021

Share "Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults"

Copied!
11
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)University of Groningen. Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults van den Berg, Sara P H; Wong, Albert; Hendriks, Marion; Jacobi, Ronald H J; van Baarle, Debbie; van Beek, Josine Published in: Frontiers in Immunology DOI: 10.3389/fimmu.2018.00082 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.. Document Version Publisher's PDF, also known as Version of record. Publication date: 2018 Link to publication in University of Groningen/UMCG research database. Citation for published version (APA): van den Berg, S. P. H., Wong, A., Hendriks, M., Jacobi, R. H. J., van Baarle, D., & van Beek, J. (2018). Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults. Frontiers in Immunology, 9, [82]. https://doi.org/10.3389/fimmu.2018.00082. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.. Download date: 17-07-2021.

(2) ÿ !" #3$%&'(ÿ7ÿ0123145ÿ789. ' (ÿ98)** +,3)789 )888 7. ‘’“”•ÿ––—“ÿ˜–ÿ‘™ÿš›“ÿ˜“ÿ˜–ÿ ’“œ“ÿ!“˜ž‘’Ÿ˜•” ›¡ÿœ–—“”˜œÿÿ ˜œÿ“¢ÿœ“”š˜£ÿ¡¤˜œ¡ÿ“˜ÿ’ÿ˜•Ÿÿ œ¥›œ¦’ÿ§’——”œÿ“ ’”œÿ”œÿ"’Ÿ“¢ÿ £›Ÿ“¡ ¨©ª©ÿ¬­ÿ®­ÿ¯©°ÿ±²°ÿµ³² ª´µ¶·¶ÿ¸¹º²ª»ÿ¼½°´¾¶ÿ¿© ªÀ½°ÿ®²°±ªÀÁµ¶ÿý°©¹±ÿ®­ÿÄ­ÿĩŽºÀµ¶ÿÿ ¶ · µ ƲººÀ²ÿ¯©°ÿ³©©ª¹² ÿ©°±ÿĽÂÀ°²ÿ¯©°ÿ³²²ÁÇ. ÿ_DEMADÿOFAÿxEOD]M@F?Lÿ‡@LD<LDÿ_FEMAF=Gÿ[<M@FE<=ÿxELM@M?MDÿOFAÿR?q=@]ÿWD<=M^ÿ<EIÿM^DÿŠEK@AFEaDEMGÿC@=M^FKDEGÿ[DM^DA=<EILGÿ ÿ‹<qFA<MFANÿFOÿvA<EL=<M@FE<=ÿxaa?EF=FZNGÿ‡DŒ<AMaDEMÿFOÿxaa?EF=FZNGÿJE@KDAL@MNÿ†DI@]<=ÿ_DEMDAÿJMAD]^MGÿJMAD]^MÿJE@KDAL@MNGÿ JMAD]^MGÿ[DM^DA=<EILGÿ{ÿ‡DŒ<AMaDEMÿFOÿPM<M@LM@]LGÿxEOFAa<M@]Lÿ<EIÿ†<M^Da<M@]<=ÿ†FID=@EZGÿ[<M@FE<=ÿxELM@M?MDÿOFAÿR?q=@]ÿWD<=M^ÿ <EIÿM^DÿŠEK@AFEaDEMGÿC@=M^FKDEGÿ[DM^DA=<EIL. ~ }. 234563ÿ89:ÿ ;<=>?@A@<ÿC?DEFGÿ HDIDA<=ÿJE@KDAL@MNÿFOÿ PQFÿR<?=FGÿCA<S@= T6U46V63ÿ89:ÿ W<ELXYAZÿW<?LDAGÿ [<M@FE<=ÿ\DLD<A]^ÿ_DEMADÿHFAÿ C@FMD]^EF=FZNGÿ`DAa<ENÿ b?<EX?Eÿc<EZGÿ d?EE<EÿeZA@]?=M?A<=ÿJE@KDAL@MNGÿ_^@E< fghii6jkhl36lm6: nFL@EDÿK<EÿCDDoÿ XFL@EDpK<EpqDDorA@KapE= sk6m4tu59ÿj6m54hl:ÿ v^@Lÿ<AM@]=Dÿw<LÿL?qa@MMDIÿ MFÿxEy<aa<M@FEGÿ <ÿLD]M@FEÿFOÿM^DÿXF?AE<=ÿ HAFEM@DALÿ@Eÿxaa?EF=FZN T6m64U63:ÿz{ÿ[FKDaqDAÿ}z~ €mm6k563:ÿ~~ÿn<E?<ANÿ}z~ ‚ƒ8u4j„63:ÿ} ÿn<E?<ANÿ}z~ g45t54hl:ÿ K<EÿIDEÿCDAZÿPRWGÿcFEZÿeGÿ WDEIA@oLÿ†Gÿn<]Fq@ÿ\WnGÿ K<EÿC<<A=Dÿ‡ÿ<EIÿK<EÿCDDoÿnÿˆ}z~‰ÿ [DZ<M@KDÿŠOOD]MÿFOÿeZDGÿq?Mÿ[FMÿFOÿ ‹<MDEMÿ_NMFaDZ<=FK@A?LÿxEOD]M@FEÿFEÿ M^DÿeEM@qFINÿ\DLŒFELDÿMFÿ<ÿ[FKD=ÿ xEy?DES<ÿ;<]]@EDÿPMA<@Eÿ@Eÿ WD<=M^NÿeI?=MLpÿ HAFEMpÿxaa?EF=pÿ }pÿ IF@ÿ~zp{{ Žaa?p}z~pzzz}. È'4ÿ1'3%ÿ14ÿ 4ÿÉ3241$ÿ ÿ2Ê32Ë1ÿÉ43%ÿ21 2ÿ12'ÿ1ÿ&/&4ÿ4%Ìÿ1 4ÿ%É4ÿ  #1 2%ÿ12'ÿ2Ê32Ë1Í41'ÿ'1&ÿ #14'ÿ ÿ5 32/4ÿ1'3%)ÿÎ21 43215Ïÿ 2Ê32Ë1ÿÉ12ÿ4%# 2%%ÿ2'ÿ ÿ$ÿ#14'ÿ2ÿ '4ÿ1'3%ÿ'3ÿ ÿ1/2/ÿ 1ÿ&ÿ 32ÿ%5%ÿÐ32 %2%2Ñ)ÿÒ12ÿ21 2ÿ0&ÿ5 /1 É43%ÿÐÓÔ

(3) Ñÿ %ÿ1%%3'ÿ ÿ2&12ÿ1/Í1%% 1'ÿ'4 3%ÿ&12/%ÿ 1ÿ&ÿ32ÿ%5%)ÿ & 3/&ÿ 04ÿ4%# 2%%ÿ ÿ2Ê32Ë1ÿÉ121 2ÿ04ÿ4# 4'ÿ2ÿÓÔ

(4) Í%4 # %Éÿ  #14'ÿ ÿÓÔ

(5) Í%4 2/1Éÿ1'3%ÿ12'ÿ'45Ïÿ$2,1ÿ11%ÿ 1ÿÓÔ

(6) ÿ21 2ÿ 04ÿ $%4É'ÿ1%ÿ0)ÿÕ&ÿ1Ìÿ 1ÿ 2%2%3%ÿ2ÿ4134ÿ 2ÿ&ÿ11ÿ 1ÿ12ÿÓÔ

(7) ÿ 21 2ÿ 2ÿ2Ê32Ë1ÿÉ121 2ÿ15ÿ$ÿ'3ÿ ÿ&ÿ#4%2ÿ 1ÿ#4ÍÖ%2/ÿ325ÿ  ÿ2Ê32Ë1ÿ2ÿ&%ÿ%3'%ÿ2Ê322/ÿ&ÿ%3$%×32ÿ2Ê32Ë1ÿÉ12ÿ4%# 2%)ÿØÿ &1'ÿ&ÿ32×3ÿ ## 4325ÿ ÿÉ131ÿ&ÿ11ÿ 1ÿ1/ÿ12'ÿ12ÿÓÔ

(8) ÿ21 2ÿ 2ÿ&ÿ 12$ '5ÿ4%# 2%ÿ ÿ&ÿ2 Éÿ2Ê32Ë1ÿÙ9Ú9#'ÿÉ12ÿ%412ÿ'342/ÿ&ÿ#12'ÿ 1ÿ788Ïÿ&4$5ÿ4'32/ÿ&ÿ11ÿ 1ÿ#4ÍÖ%2/ÿ325ÿ 2ÿ&ÿÉ12Í2'3'ÿ 12$ '5ÿ4%# 2%)ÿÕ&%ÿ1215%%ÿ01%ÿ#41 4'ÿ2ÿ1ÿ14/ÿ%3'5ÿ# #31 2ÿÐEÿÜÿ7Ý*Ñÿ2ÿ 1'3%ÿÐ9 Þß7ÿ514%ÿ 'Ñ)ÿ%ÿ1ÿ 24 Ïÿ 45ÿ4%# 2%%ÿ ÿ&ÿ%1% 21ÿÉ121 2Ïÿ 23'2/ÿ&ÿ%1ÿÙ9Ú9#'ÿ12'ÿ12ÿÙ*Ú7ÿ%412Ïÿ04ÿ2É%/1'ÿ2ÿ&ÿ%3$%×32ÿ %1% 2ÿ7898Þ7899)ÿØ&ÿ&/&4ÿ1/Ïÿ0ÿ1 32'ÿ'41%'ÿ12$ '5ÿ4%# 2%%ÿ ÿ&ÿ #12'ÿÉ121 2ÿÉ2ÿ0&2ÿ&%ÿ1/ÿ412/Ïÿ2'12/ÿ%/2%ÿ 1ÿ32 %2%Í 2ÿ ÿ&%ÿ2 Éÿ12/2ÿ2ÿ&ÿ%3'5ÿ# #31 2)ÿÎ%2/ÿ1ÿ/241Ë'ÿ%1 2ÿ ×31 2ÿ4/4%% 2ÿ 'Ïÿ1'à3%'ÿ1 4ÿ1/Ïÿ%ÖÏÿ12'ÿ#4É 3%ÿ2Ê32Ë1ÿÉ121 2%Ïÿ 0ÿ $%4É'ÿ&1ÿÓÔ

(9) ÿ21 2ÿ2ÿ 241%ÿ''ÿ2 ÿ2Ê32ÿ&ÿ2Ê32Ë1ÿÉ43%Í%#,ÿ 12$ '5ÿ4ÿ114ÿÙ9Ú9#'ÿÉ121 2)ÿáÏÿ0ÿ1 32'ÿ&/&4ÿ4%'31ÿ#4  2ÿ41%ÿ Ð12$ '5ÿÉÿâã8ÿ&1//322ÿ32%ÿÐÙÎÑÑÿ2ÿÓÔ

(10) Í%4 # %Éÿ2'É'31%ÿ&12ÿ2ÿ ÓÔ

(11) Í%4 2/1Éÿ2'É'31%ÿÝÿ 2&%ÿ12'ÿ9ÿ514ÿ114ÿ#12'ÿÉ121 2)ÿ.2ÿ&ÿ %3$%×32ÿ%1% 2Ïÿ2 ÿ11ÿ 1ÿ1/ÿ 4ÿÓÔ

(12) ÿ21 2ÿ 2ÿ%1% 21ÿ2Ê32Ë1ÿÉ12ÿ. -4 24%ÿ2ÿ.32  /5ÿ ÿ000)14 24%2) 4/. . 0123145ÿ789 ÿ ÿ

(13) 3ÿÿ ÿ4ÿ 7.

(14) 123ÿ563ÿ7689ÿ6 ÿ2

(15). ÿÿÿÿ. 86$5"3$6ÿ*2$ÿ"6$68165

(16) ÿ%3ÿ4"34 '$#"37ÿ*6ÿ"6$68165ÿ3"ÿ61#56346ÿ+"8ÿ891:#35'465ÿ #&52#8&63 ÿ"+ÿ23 #6"5(ÿ86$5"3$6$ÿ "ÿ2ÿ3"16 ÿ#3;'63<2ÿ$ 82#3ÿ1244#36ÿ#3ÿ25' $

(17) ÿ%+ÿ23(:. =#397ÿ"'8ÿ52 2ÿ$'996$ ÿ =2 ÿ =686ÿ&#9= ÿ66ÿ2ÿ6636>4#2 ÿ6++64 ÿ"+ÿ 2 63 ÿ891ÿ#3+64 #"3ÿ"3ÿ. =6ÿ58" 64 #"3ÿ82 6ÿ2+ 68ÿ3"16 ÿ#3;'63<2ÿ1244#32 #"3

(18) ?@ABCDEFGÿIAJCK@LMNCOPDQFRÿPSTQ@SUMÿOMIIPS@RÿMLPSLRÿPKKQSCF@S@FI@SI@RÿVMSE@KPIRÿMSJPWCEAÿD@FVCSF@Rÿ XYÿ[\]\ÿPKKQS@ÿD@FVCSF@. ^_`abcde`^b_. fghigÿklÿmnoÿpkpqrsmhkiÿpktotÿsiÿhupkvmsimÿpqwrhxÿnosrmnÿ pvkwrouyÿzhmnÿsgo{ÿmnoÿlqixmhkiÿklÿmnoÿnqusiÿhuuqioÿt|tmouÿ }oxrhiot{ÿsÿpnoikuoikiÿsrtkÿvolovvo}ÿmkÿstÿhuuqiktoiotxoixoÿ ~€yÿvklkqi}ÿxnsigotÿklÿmnoÿhuuqioÿt|tmouÿhixrq}oÿmnoÿgvs}qsrÿ rkttÿklÿis‚ƒoÿxorrt{ÿhixvostoÿklÿuoukv|ÿxorrÿiquwovt{ÿsi}ÿ}oxvosto}ÿ }hƒovthm|ÿklÿmnoÿ„ÿxorrÿsi}ÿ†ÿxorrÿvopovmkhvoÿ~‡ˆ€yÿ‰otoÿxnsigotÿ xkimvhwqmoÿmkÿvo}qxo}ÿpvkmoxmhkiÿsgshitmÿhiloxmhkqtÿ}htostotÿsi}ÿ vo}qxo}ÿƒsxxhioÿvotpkitotÿhiÿkr}ovÿs}qrmtyÿŠi}oo}{ÿmnoÿhixh}oixoÿ klÿhi‹qoiŒsÿƒhvqtÿhiloxmhkitÿhtÿhixvosto}ÿsi}ÿsxxkupsiho}ÿhmnÿ ukvoÿxkuprhxsmhkitÿsi}ÿnhgnovÿukvmsrhm|ÿhiÿkr}ovÿs}qrmtÿ~Ž{ÿ€yÿ ktmÿ}oƒorkpo}ÿxkqimvhotÿvoxkuuoi}ÿ|osvr|ÿhi‹qoiŒsÿƒsxxhis‘ mhkiÿhiÿhi}hƒh}qsrtÿswkƒoÿ’“ÿkvÿ’ÿ|osvtÿklÿsgoÿ~’€{ÿhiÿkv}ovÿmkÿ pvoƒoimÿhi‹qoiŒsÿƒhvqtÿhiloxmhkiÿw|ÿmnoÿhi}qxmhkiÿklÿpvkmoxmhƒoÿ simhwk}hotÿ~Ž{ÿ”€yÿ•koƒov{ÿmnoÿsimhwk}|ÿvotpkitoÿmkÿhi‹qoiŒsÿ ƒsxxhismhkiÿhiÿkr}ovÿs}qrmtÿhtÿhupshvo}{ÿxsqthigÿsÿtqwkpmhusrÿ pvkmoxmhkiÿhiÿmnhtÿƒqriovswroÿgvkqpÿ~”‡–€y fxxquqrsmhigÿoƒh}oixoÿhi}hxsmotÿmnsmÿrsmoimÿx|mkuogsrk‘ ƒhvqtÿ~—˜€ÿhiloxmhkiÿhtÿsttkxhsmo}ÿhmnÿsgo‘vorsmo}ÿxnsigotÿ klÿmnoÿhuuqioÿt|tmou{ÿsi}ÿuhgnmÿoinsixoÿhuuqiktoiotxoixoÿ ~™{ÿ“{ÿ€yÿ—˜ÿhtÿsÿxkuukiÿš‘novpotƒhvqtÿhmnÿsÿpvoƒsroixoÿ klÿŽ‡““›ÿkvr}h}o{ÿnhxnÿhixvostotÿhmnÿs}ƒsixhigÿsgoÿ ~™€yÿ—˜ÿhiloxmhkiÿxsqtotÿukvwh}hm|ÿsi}ÿukvmsrhm|ÿhiÿtoƒovor|ÿ huuqikxkupvkuhto}ÿpsmhoimt{ÿnhroÿmnoÿƒhvqtÿvsvor|ÿxsqtotÿ xrhihxsrÿt|upmkutÿhiÿnosrmn|ÿhi}hƒh}qsrtyÿœotphmoÿmnoÿswhrhm|ÿ klÿmnoÿhuuqioÿt|tmouÿmkÿxkimvkrÿpvhusv|ÿhiloxmhki{ÿmnoÿƒhvqtÿ otmswrhtnotÿsÿrsmoimÿhiloxmhki{ÿhmnÿophtk}otÿklÿƒhvsrÿvosxmhƒsmhkiÿ }qvhigÿrhlomhuoÿ~ˆ€yÿ‰oÿlvoqoimÿvosxmhƒsmhkiÿklÿ—˜ÿxsqtotÿ xkimhiqkqtÿsimhgoihxÿtmvottÿlkvÿmnoÿhuuqioÿt|tmouÿ~ˆ€yÿfimh‘ —˜ÿŠgžÿroƒortÿhixvostoÿhmnÿsgoÿ~Ž‡’€ÿsi}ÿsvoÿmnkqgnmÿmkÿ hixvostoÿsŸovÿƒhvsrÿvosxmhƒsmhkiÿophtk}ot{ÿmnovow|ÿvo‹oxmhigÿmnoÿ sukqimÿklÿo povhoixo}ÿ—˜ÿsimhgoihxÿtmvottÿ}qvhigÿrhlomhuoÿ ~™{ÿŽ{ÿ”€yÿ‰ oÿpvklkqi}ÿo¡oxmÿklÿ—˜ÿhiloxmhkiÿkiÿmnoÿhuuqioÿ t|tmouÿhtÿotpoxhsrr|ÿtnkiÿw|ÿmnoÿpvkgvotthƒoÿrsvgoÿo psithkiÿklÿ krhgkxrkisrÿ—˜‘tpoxh¢xÿ—œ£ÿ„ÿxorrtÿsi}{ÿmkÿsÿrottovÿo moim{ÿ—œŽÿ „ÿxorrtyÿ¤qvmnovukvo{ÿ—˜‘tovkpkthmhƒhm|ÿhtÿtmvkigr|ÿsttkxhsmo}ÿ hmnÿsiÿhiƒovmo}ÿ—œŽ¥£ÿvsmhkÿ~£€{ÿwhstÿklÿmnoÿ„—¦ÿvopovmkhvoÿ~–€{ÿ si}ÿsiÿhixvostoÿklÿnhgnr|ÿ}h¡ovoimhsmo}ÿ„ÿxorrtÿ~™“€y Šmÿnstÿwooiÿtqggotmo}ÿmnsmÿ—˜‘oinsixo}ÿhuuqiktoiotxoixoÿ xkqr}ÿhupshvÿmnoÿhuuqioÿvotpkitoÿmkÿhi‹qoiŒsÿƒsxxhismhkiÿ ~™{ÿ™™€yÿŠi}oo}{ÿhiÿtoƒovsrÿtmq}hot{ÿ—˜‘tovkpkthmhƒhm|ÿkvÿsÿnhgnÿ simh‘—˜ÿŠgžÿmhmovÿstÿsttkxhsmo}ÿhmnÿrkovÿsimhwk}|ÿvotpkitotÿ mkÿhi‹qoiŒsÿƒsxxhismhkiÿhiÿwkmnÿs}qrmtÿ~™ˆ‡™€ÿsi}ÿkr}ovÿs}qrmtÿ ~™‡™£€yÿ•koƒov{ÿkmnovtÿ}h}ÿikmÿ¢i}ÿsiÿo¡oxmÿklÿ—˜ÿhilox‘ mhkiÿ~™–{ÿˆ“€{ÿkvÿvopkvmo}ÿoƒoiÿsiÿoinsixo}ÿsimhwk}|ÿvotpkitoÿ mkÿhi‹qoiŒsÿƒsxxhismhkiÿhiÿwkmnÿ|kqigÿ~ˆ{ÿˆ™€ÿsi}ÿkr}ovÿ —˜‘tovkpkthmhƒoÿhi}hƒh}qsrtÿ~ˆˆ€y !8"3 #68$ÿ#3ÿ%&&'3" "9(ÿ)ÿ***

(19) +8"3 #68$#3

(20) "89. 0. ‰oÿkƒovsrrÿhupsxmÿklÿrsmoimÿ—˜ÿhiloxmhkiÿkiÿmnoÿsimhwk}|ÿ hi}qxmhkiÿw|ÿhi‹qoiŒsÿƒsxxhiotÿvoushitÿxkimvkƒovthsrÿsi}ÿ }opoi}t{ÿsukigÿkmnovÿlsxmkvt{ÿkiÿpvo‘o htmhigÿhuuqihm|ÿmkÿ hi‹qoiŒsÿƒhvqtÿ~ˆŽ€yÿktmÿtmq}hotÿhiƒotmhgsmo}ÿmnoÿsimhwk}|ÿ votpkitoÿmkÿtostkisrÿhi‹qoiŒsÿƒsxxhismhki§ÿsÿ|osvr|ÿvoxku‘ uoi}o}ÿmvhƒsroimÿhi‹qoiŒsÿƒsxxhioÿmnsmÿkŸoiÿxkimshitÿkƒovrsp‘ phigÿhi‹qoiŒsÿƒsxxhioÿtmvshitÿhiÿxkitoxqmhƒoÿ|osvtyÿ¨smqvsrÿ o pktqvoÿmkÿhi‹qoiŒsÿƒhvqtÿsi}ÿpvoƒhkqtÿƒsxxhismhkiÿxsqtotÿ pvo‘o htmhigÿhuuqihm|{ÿnhxnÿhi‹qoixotÿmnoÿxkitoxqmhƒoÿƒsxxhioÿ votpkitoyÿ•hgnovÿpvo‘ƒsxxhismhkiÿsimhwk}|ÿmhmovtÿ~pvo‘mhmovt€ÿ hi}oo}ÿovoÿtnkiÿmkÿvotqrmÿhiÿrkovÿpktm‘ƒsxxhismhkiÿsimhwk}|ÿ mhmovtÿmkÿtqwtoqoimÿƒsxxhismhkiÿ~”{ÿˆ€yÿ¤qvmnovukvo{ÿkioÿxkqr}ÿ o poxmÿsÿrsvgovÿo¡oxmÿklÿhuuqiktoiotxoixoÿkiÿ©ªÿ¬­®­ÿhuuqioÿ votpkitotÿ~ˆ’{ÿˆ”€yÿfÿtostkisrÿhi‹qoiŒsÿƒsxxhismhkiÿht{ÿmnovolkvo{ÿ sÿtqwkpmhusrÿtmq}|ÿtommhigÿmkÿhiƒotmhgsmoÿmnoÿo¡oxmÿklÿrsmoimÿ—˜ÿ hiloxmhkiÿkiÿhi‹qoiŒsÿƒsxxhioÿsimhwk}|ÿvotpkitoy zoÿn|pkmnothŒoÿmnsmÿmnoÿo¡oxmÿklÿrsmoimÿ—˜ÿhiloxmhkiÿkiÿmnoÿ simhwk}|ÿvotpkitoÿmkÿhi‹qoiŒsÿƒsxxhismhkiÿxsiÿwotmÿwoÿtmq}ho}ÿ noiÿsÿikƒorÿhi‹qoiŒsÿƒhvqtÿtmvshiÿhtÿhimvk}qxo}ÿhimkÿsÿis‚ƒoÿ pkpqrsmhkiyÿŠiÿmnhtÿtmq}|{ÿoÿns}ÿmnoÿqihqoÿkppkvmqihm|ÿmkÿ hiƒotmhgsmoÿmnoÿo¡oxmÿklÿrsmoimÿ—˜ÿhiloxmhkiÿkiÿmnoÿsimhwk}|ÿ votpkitoÿ}qvhigÿmnoÿpsi}ouhxÿtostkiÿklÿ™““–ÿmkÿmnoÿikƒorÿ •¨p}uÿƒsxxhioÿtmvshiÿhiÿsÿrsvgoÿtmq}|ÿpkpqrsmhkiÿsi}ÿsmÿ uqrmhproÿmhuoÿpkhimtÿsŸovÿƒsxxhismhkiyÿ‰htÿsrrko}ÿsÿtkpnhtmh‘ xsmo}ÿtmq}|ÿ}othgiÿmkÿmotmÿmnoÿo¡oxmÿklÿrsmoimÿ—˜ÿhiloxmhkiÿkiÿsÿ ©ªÿ¬­®­ÿhi‹qoiŒsÿƒsxxhioÿvotpkitoÿw|ÿuhihuhŒhigÿpvo‘o htmhigÿ huuqihm|ÿ}qoÿmkÿpvoƒhkqtÿo pktqvoÿw|ÿƒsxxhismhkiÿkvÿismqvsrÿ hiloxmhkiyÿftÿsÿxkimvkr{ÿmnoÿhi‹qoixoÿklÿrsmoimÿ—˜ÿhiloxmhkiÿ kiÿmnoÿuoukv|ÿsimhwk}|ÿvotpkitoÿmkÿmnoÿƒsxxhismhkiÿhiÿmnoÿ tqwtoqoimÿ|osvÿstÿsrtkÿhiƒotmhgsmo}{ÿnhxnÿhixrq}o}ÿwkmnÿmnoÿ tsuoÿ•¨p}uÿƒsxxhioÿtmvshiÿsi}ÿsiÿ•ˆ¨™ÿƒsxxhioÿtmvshiy. ¯°`±a^°²³ÿ°_cÿ¯±`´bc³ ³J QEAÿµCVQNMJPCSÿMSEÿc@FPLS ‰oÿxqvvoimÿtmq}|ÿhtÿouwo}}o}ÿhiÿsÿmvhsrÿmnsmÿoƒsrqsmo}ÿmnoÿ. huuqioÿvotpkitotÿmkÿpsi}ouhxÿsi}ÿtostkisrÿhi‹qoiŒsÿƒsxxhis‘ mhkiÿmnsmÿstÿxki}qxmo}ÿhiÿ™““–‡™“ÿ~mnoÿsi}ouhxÿhi‹qoiŒsÿ ƒsxxhismhkiÿmvhsr{ÿ¨omnovrsi}tÿ„vhsrÿ¦oghtmovÿ¨„¦™“”“€yÿ‰htÿ tmq}|ÿstÿxsvvho}ÿkqmÿhiÿsxxkv}sixoÿhmnÿmnoÿvoxkuuoi}s‘ mhkitÿklÿžkk}ÿ—rhihxsrÿvsxmhxoÿhmnÿvhmmoiÿhilkvuo}ÿxkitoimÿ lvkuÿsrrÿtqw¶oxmtyÿfrrÿtqw¶oxmtÿgsƒoÿvhmmoiÿhilkvuo}ÿxkitoimÿ hiÿsxxkv}sixoÿhmnÿmnoÿœoxrsvsmhkiÿklÿ•orthi·hyÿ‰oÿpvkmkxkrÿ stÿsppvkƒo}ÿw|ÿmnoÿ—oimvsrÿ—kuuhmmooÿkiÿ¦otosvxnÿŠiƒkrƒhigÿ •qusiÿ¸qw¶oxmtÿklÿmnoÿ¨omnovrsi}tyÿ•osrmn|ÿhi}hƒh}qsrt{ÿ womooiÿ£ÿsi}ÿ™ÿ|osvtÿklÿsgo{ÿovoÿvoxvqhmo}ÿsukigÿnosrmnÿ xsvoÿkv·ovtÿhiÿmnoÿ¹mvoxnmÿsvosÿhiÿmnoÿ¨omnovrsi}tyÿŠi}hƒh}qsrtÿ ,23'28(ÿ-./0ÿ)ÿ1" '&6ÿ2ÿ)ÿ38 #4 6ÿ0-.

(21) ÿ ÿB.ÿ ÿ. CDEÿGHHIJKÿLMNOIPQJÿRNSTINUMÿEMJJQNMKQVN. YZ[\ÿ^_ÿa[b\cÿYdÿbe[ÿf[\[ÿgYhÿigjklm[mÿn[jblc[ÿYdÿoYh[ghibkÿo\[p [qichigeÿirrlgihaÿml[ÿhYÿ[qoYcl\[ÿhYÿhs[ÿigtl[gubÿvwxyzyÿ ch\bigÿhsbhÿji\jlkbh[mÿlghikÿy{^|ÿ}~€ÿ‚[\lrÿcbrok[cÿbgmÿƒl[cp hiYggbi\[cÿf[\[ÿlc[mÿd\Yrÿhs[ÿZbjjig[ÿe\YloÿYdÿhs[ÿ„bgm[rijÿ igtl[gubÿZbjjigbhiYgÿjYsY\h. Zbjjig[ÿch\bigcÿvw‘bkidY\gibw|w_’’{}xyzyomr’{€ÿbgmÿvw„[\hswÿ y—w_’’{}x~z_€ÿ}‚YkZbaÿhs[ÿz[hs[\kbgmc€ÿ”kYYmÿfbcÿjYkk[jh[mÿ n[dY\[ÿZbjjigbhiYgÿ}•y€ÿ~ÿf[[“cÿb–[\ÿZbjjigbhiYgÿ}•_€ÿbgmÿ _’ÿf[[“cÿb–[\ÿZbjjigbhiYgÿ}•~€. rYgYZbk[ghÿŽ^{pbmlZbgh[mÿigtl[gubÿZbjjig[ÿjYghbigigeÿ igtl[gubÿvw‘bkidY\gibw|w_’’{}xyzyomr’{€ÿfihsÿbÿ~pf[[“ÿ igh[\Zbkÿ}Yj[h\ibÿzYZb\hicÿŒhbka€ÿ”kYYmÿcbrok[cÿf[\[ÿjYkp k[jh[mÿn[dY\[ÿZbjjigbhiYgÿ}•y€ÿ~ÿf[[“cÿb–[\ÿZbjjigbhiYgÿ bhÿfsijsÿbkcYÿhs[ÿc[jYgmÿobgm[rijÿZbjjig[ÿmYc[ÿfbcÿeiZ[gÿ }•_€ÿ—ÿf[[“cÿb–[\ÿhs[ÿ˜\chÿZbjjigbhiYgÿ}•~€ÿ_—ÿf[[“cÿb–[\ÿ hs[ÿ˜\chÿZbjjigbhiYgÿ}•™€ÿbgmÿidÿob\hijiobghcÿjYghigl[mÿfihsÿ hs[ÿchlmaÿml\igeÿhs[ÿ_’y’š_’yyÿc[bcYgÿbkcYÿ^_ÿf[[“cÿb–[\ÿhs[ÿ ˜\chÿZbjjigbhiYgÿ}•^€ÿ}›œžŸ ÿ¢€ÿ‚[kdp\[oY\h[mÿZbjjig[ÿsichY\aÿ }_’’—š_’’{€ÿfbcÿ[qh\bjh[mÿd\Yrÿhs[ÿƒl[chiYggbi\[cÿŒdÿchlmaÿ cln[jhcÿ\[j[iZ[mÿc[bcYgbkÿh\iZbk[ghÿZbjjigbhiYgÿigÿ_’’{š_’y’ÿ }‚YkZbaÿhs[ÿz[hs[\kbgmc€ÿihÿhYY“ÿokbj[ÿbhÿk[bchÿ~ÿf[[“cÿo\iY\ÿhYÿ hs[ÿchlmaÿY\ÿbhÿhs[ÿ[gmÿYdÿZicihÿbhÿhir[ÿoYighÿ~ÿYdÿhs[ÿchlmaÿŒgÿ c[bcYgÿ_’y’š_’yyÿigmiZimlbkcÿ\[j[iZ[mÿhs[ÿc[bcYgbkÿh\iZbk[ghÿ clnlgihÿZbjjig[ÿŒgtlZbjÿ_’y’š_’yyÿjYghbigigeÿhs[ÿigtl[gubÿvÿ. bÿjYrr[\jibkÿ³´Œ‚vÿ}Œ”´ÿigh[\gbhiYgbkÿ²Ž”xÿxbrnl\eÿ ²[\rbga€ÿbjjY\migeÿhYÿrbgldbjhl\[\µcÿigch\ljhiYgcÿ„b\hijiobghcÿ fihsÿbÿ‘Ž±ÿbghinYmaÿk[Z[kÿYdÿ¶y_ÿ·wrkÿY\ÿsies[\ÿf[\[ÿjYgp cim[\[mÿ‘Ž±pc[\YoYcihiZ[ÿbÿk[Z[kÿYdÿ¸ÿ·wrkÿf[\[ÿjYgcim[\[mÿ ‘Ž±pc[\Yg[ebhiZ[ÿbgmÿbÿk[Z[kÿn[hf[[gÿÿbgmÿy_ÿ·wrkÿfbcÿ jYgcim[\[mÿ[ƒliZYjbkÿbgmÿhs[c[ÿob\hijiobghcÿf[\[ÿ[qjklm[mÿdY\ÿ dl\hs[\ÿbgbkacicÿ‘Ž±pc[\YoYcihiZ[ÿigmiZimlbkcÿf[\[ÿmiZim[mÿ ighYÿkYfÿbghip‘Ž±ÿk[Z[kcÿ}¸~’ÿ·wrk€ÿr[milrÿbghip‘Ž±ÿk[Z[kcÿ }¹~’ÿ·wrkÿ¸{’ÿ·wrk€ÿY\ÿsiesÿbghip‘Ž±ÿk[Z[kcÿ}¹{’ÿ·wrk€ÿ bjjY\migeÿhYÿhs[ÿchbgmb\mcÿigÿhs[ÿ‘Ž±ÿ³´Œ‚vÿ“ih. ‹Š‹‹£Š‰¤ÿ¥¦ÿ§Š¨©£ÿ(‰¤ˆª«¬ ÿÿ Œg†ÿh‡s[‡ÿoˆ‰bgŠm‹[rijÿc[bcYgÿigmiZimlbkcÿ\[j[iZ[mÿhfYÿmYc[cÿYdÿhs[ÿ (‹ (‰ ¤ˆ­¥®¯ÿ°ˆ¤Š¨‹ vghip‘Ž±ÿŒe²ÿbghinYmaÿjYgj[gh\bhiYgcÿf[\[ÿr[bcl\[mÿlcigeÿ. ºŠ £†»»¼©¤ˆ‰†¤ˆ¥‰ª1‰½ˆ­ˆ¤ˆ¥‰ÿ'º1)ÿ(‹‹†¯ x[rbeeklhigbhiYgpigsinihiYgÿbccbacÿf[\[ÿo[\dY\r[mÿigÿhs[ÿ. obgm[rijÿc[bcYgÿdY\ÿvw‘bkidY\gibw|w_’’{}xyzyomr’{€ÿbgmÿigÿ c[bcYgÿ_’y’š_’yyÿdY\ÿvw‘bkidY\gibw|w_’’{}xyzyomr’{€ÿbgmÿ vw„[\hswy—w_’’{}x~z_€ÿhYÿm[h[\rig[ÿigtl[gubÿZi\lcpco[ji˜jÿ bghinYmaÿhih[\cÿn[dY\[ÿbgmÿb–[\ÿZbjjigbhiYgÿ”\i[taÿbÿmiklhiYgÿ c[\i[cÿYdÿjsYk[\bÿ˜kh\bh[ph\[bh[mÿc[\lrÿcbrok[cÿfbcÿigjlnbh[mÿ fihsÿdYl\ÿs[rbeeklhigigÿlgihcÿ}xv·€ÿYdÿigtl[gubÿZi\lcÿdY\ÿ _’ÿrigÿ’_^¾ÿhl\“[aÿ[\ahs\Yjah[cÿdY\ÿ™^ÿrigÿbgmÿcjY\[mÿdY\ÿ beeklhigbhiYgÿ}~{€ÿ¿[ÿigtl[gubÿbghinYmaÿhih[\ÿicÿhs[ÿigZ[\c[ÿYdÿ hs[ÿkbchÿmiklhiYgÿYdÿhs[ÿc[\lrÿhsbhÿjYrok[h[kaÿigsinih[mÿs[rbep eklhigbhiYgÿvÿm[h[jhbnk[ÿigtl[gubÿbghinYmaÿnYmaÿhih[\ÿicÿm[˜g[mÿ bcÿ¹^ÿxv·. §¤ †¤ˆ‹¤ˆ‡†¼ÿ(‰†¼¯‹ˆ‹ vghinYmaÿ\[coYgc[cÿhYÿxyzyomrÿigtl[gubÿZbjjigbhiYgÿigÿhs[ÿ. obgm[rijÿc[bcYgÿf[\[ÿ[qo\[cc[mÿigÿhfYÿmiÀ[\[ghÿfbacÁÿ}y€ÿigtlp [gubÿbghinYmaÿhih[\ÿbgmÿ}_€ÿo\Yh[jhiYgÿ\bh[ÿ}bghinYmaÿhih[\ÿ¶™’ÿ xv·€ÿY\ÿbkkÿchbhichijbkÿbgbkac[cÿigtl[gubÿbghinYmaÿhih[\cÿf[\[ÿ kYeÿ}nbc[ÿ_€ÿh\bgcdY\r[mÿbgmÿo\[c[gh[mÿbcÿe[Yr[h\ijÿr[bgÿhih[\ÿ }²Ž•€ÿfihsÿ{^¾ÿjYg˜m[gj[ÿigh[\Zbkÿ}‘Œ€ÿigÿhs[ÿ˜el\[c i\chÿbÿhfYphbik[mÿ‚hlm[ghµcÿÂph[chÿ}dY\ÿhfYÿe\Yloc€ÿY\ÿYg[p fbaÿvzñvÿ}dY\ÿhs\[[ÿY\ÿrY\[ÿe\Yloc€ÿfbcÿlc[mÿhYÿ[qokY\[ÿ e\YloÿmiÀ[\[gj[cÿigÿigtl[gubÿbghinYmaÿhih[\cÿ}[eÿn[hf[[gÿkYfÿ r[milrÿbgmÿsiesÿ‘Ž±ÿŒe²ÿe\Yloc€ÿY\ÿhs[ÿhfYphbik[mÿÄph[chÿ [ƒlbkihaÿYdÿZb\ibgj[cÿfbcÿh[ch[mÿfihsÿ´[Z[g[µcÿh[chÿdY\ÿ[ƒlbkihaÿ ²\YloÿmiÀ[\[gj[cÿigÿjbh[eY\ijbkÿZb\ibnk[cÿf[\[ÿjYrob\[mÿfihsÿ hs[ÿics[\ÿ[qbjhÿh[ch ‚[jYgmÿf[ÿigZ[chiebh[mÿhs[ÿ[À[jhÿYdÿkbh[ghÿ‘Ž±ÿigd[jhiYgÿigÿ bÿrlkhiZb\ibh[ÿjYgh[qhÅÿhs[ÿ[À[jhÿYdÿ‘Ž±ÿigd[jhiYgÿYgÿigtl[gubÿ bghinYmaÿhih[\cÿfbcÿbmlch[mÿdY\ÿoYh[ghibkÿjYgdYlgm[\cÿlcigeÿ bÿe[g[\bkiu[mÿ[chirbhiYgÿ[ƒlbhiYgÿ}²³³€ÿ\[e\[cciYgÿrYm[kÿ }•bnk[ÿ‚yÿigÿ‚look[r[ghb\aÿŽbh[\ibk€ÿ}™’€ÿ¿icÿrYm[kÿhb“[cÿ \[o[bh[mÿr[bcl\[r[ghcÿdY\ÿhs[ÿcbr[ÿigmiZimlbkcÿighYÿbjjYlghÿ Y\ÿhs[ÿjYghigl[cÿZb\ibnk[ÿYlhjYr[ÿ}igtl[gubÿbghinYmaÿhih[\€ÿ hs[ÿgY\rbkÿmich\inlhiYgÿbgmÿdY\ÿhs[ÿjbh[eY\ijbkÿZb\ibnk[ÿ}igtlp [gubÿo\Yh[jhiYgÿ\bh[€ÿhs[ÿnigYribkÿmich\inlhiYgÿYdÿhs[ÿrYm[kÿ. 012345ÿ7ÿ8ÿ

(22) ÿ

(23) ÿ  ÿ ÿÿ ÿ ÿÿ ÿ ÿ

(24) ÿ!"#" ÿ ÿ ÿÿ$%&ÿ ÿÿ '()ÿ*ÿ  +ÿ,-$ÿ .

(25) ÿ/0123% ÿ ÿ012%. ÿ  

(26) ÿÿ  ÿ"44ÿ  ÿ 

(27)  ÿ5ÿ ÿ

(28) 67

(29)  ÿ ÿÿ ÿ

(30) ÿ/84ÿÿ"3ÿ*ÿ ÿÿ,9"9:,9""+ÿ",;ÿ 

(31) ÿ ÿ  ÿ/8"ÿÿ,3ÿ ÿ ÿÿ  ÿ

(32) ÿ  ÿÿ  ÿ.ÿ ÿ ÿÿ!"#" ÿÿ  ÿ ÿÿ!$#,ÿÿ ÿ'<)ÿ=ÿ/>3ÿ  ÿ ÿ ÿ5ÿ  ÿ8ÿ ÿ/83ÿ  ÿ ÿ ÿ5ÿ6 ÿ  ÿ?ÿ ÿ ÿ +ÿ ÿ

(33) 6ÿ/@3ÿ5ÿ 

(34) ÿ ÿ  ÿ5ÿ

(35) ÿ 6 ÿ ÿÿ    ? ÿÿ*

(36) .ÿ8ÿ5 .. A. W

(37) ÿ,9";ÿ8ÿ2

(38) ÿXÿ8ÿ= ÿ;,.

(39) U ÿÿ‡

(40) Cÿÿ . ˆ‰ŠÿŒŽÿ‘’“”Ž•–ÿ—“˜™Ž“š’ÿŠ’–“’–›“. ¡¢£ÿ¥£¦§¨ÿ©¦ÿ¦ª¦«¬ÿ­®ÿ¯°±ÿ²³®¦«¬²­³ÿ¡¢£ÿ²³´¦£¬²µ¢¬¦§ÿ²³ÿ¬¡­ÿ ¡¢¶£·ÿ¸¢¹ÿ¯°±º£¦»­£¬¢¬¥£·ÿ¯°±º£¦»­¼­£²¬²´¦ÿ²³§²´²§¥¢½£ÿ¡¦»¦ÿ «­¾ÿ¼¢»¦§ÿ¬­ÿ¯°±º£¦»­³¦µ¢¬²´¦ÿ²³§²´²§¥¢½£ÿ¢³§ÿ¸¿¹ÿ¢³¬²º¯°±ÿ ÀµÁÿµ»­¥¼£·ÿ½­¡Âÿ¾¦§²¥¾Âÿ¢³§ÿòµÃÿ¢³¬²º¯°±ÿÀµÁÿ½¦´¦½£ÿ¡¦»¦ÿ «­¾¼¢»¦§ÿ¡²¬Ã²³ÿ¯°±º£¦»­¼­£²¬²´¦ÿ²³§²´²§¥¢½£¨ÿ¯­³®­¥³§¦»£ÿ ²³«½¥§¦§ÿ¡¦»¦ÿ¢µ¦Âÿ£¦ÄÂÿ¬²¾¦Âÿ¢³§ÿ´¢»²­¥£ÿ´¢»²¢¿½¦£ÿ«­³«¦»³²³µÿ ´¢««²³¢¬²­³ÿò£¬­»¶ÿ¸£¦¦ÿÅ¢¿½¦ÿÆÇÿ²³ÿÆ¥¼¼½¦¾¦³¬¢»¶ÿ°¢¬¦»²¢½¹¨ÿ ©¦ÿ¾­§¦½ÿ¶²¦½§¦§ÿ¢ÿ¿¦¬¢ÿ»¦µ»¦££²­³ÿ«­¦È«²¦³¬ÿ®­»ÿ¦¢«Ãÿ´¢»²¢¿½¦Âÿ ¡Ã²«Ãÿ»¦É¦«¬£ÿí¡ÿ¢ÿ«¢¬¦µ­»¶ÿ¸¦¨µ¨ÂÿòµÃ¦£¬ÿ¢µ¦ÿµ»­¥¼¹ÿ«­¾¼¢»¦£ÿ ¬­ÿ¬Ã¦ÿ»¦®¦»¦³«¦ÿ«¢¬¦µ­»¶ÿ¸¦¨µ¨Âÿ½­¡¦£¬ÿ¢µ¦ÿµ»­¥¼¹¨ÿʦµ»¦££²­³ÿ «­¦È«²¦³¬£ÿ­®ÿ¬Ã¦ÿÁËËÿ¾­§¦½£ÿ¢»¦ÿµ²´¦³ÿ²³ÿÅ¢¿½¦£ÿÆÌÍÆÎÿ²³ÿ Æ¥¼¼½¦¾¦³¬¢»¶ÿ°¢¬¦»²¢½¨ÿ©¦ÿ¾­§¦½ÿ¢½£­ÿ¶²¦½§¦§ÿ¢§Ï¥£¬¦§ÿ »¦£¥½¬£ÿ¸²¨¦¨Âÿ²³É¥¦³Ð¢ÿ¢³¬²¿­§¶ÿ¬²¬¦»£ÿ­»ÿ¼»­¬¦«¬²­³ÿ»¢¬¦£¹ÿ®­»ÿ ¦¢«Ãÿ¬²¾¦ÿ¼­²³¬ÿ¢¬ÿ¡Ã²«Ãÿ«­¾¼¢»²£­³£ÿ¿¦¬¡¦¦³ÿ¯°±º£¦»­£¬¢¬¥£ÿ ­»ÿ¢³¬²º¯°±ÿÀµÁÿµ»­¥¼ÿ¡¦»¦ÿ¼¦»®­»¾¦§Âÿ¿¶ÿ²³«½¥§²³µÿ¢³ÿ²³¬¦»º ¢«¬²­³ÿ¬¦»¾ÿ¿¦¬¡¦¦³ÿ¬²¾¦ÿ¢³§ÿ¯°±º£¦»­£¬¢¬¥£ÿ­»ÿ¢³¬²º¯°±ÿ ÀµÁÿµ»­¥¼ÿ²³ÿ¬Ã¦ÿÁËËÿ¾­§¦½£¨ÿ©¦ÿ¢§Ï¥£¬¦§ÿ­¥¬«­¾¦£ÿ­®ÿ¬Ã¦ÿ ¾­§¦½£ÿ¢³§ÿ¼¢²»¡²£¦ÿ«­¾¼¢»²£­³£ÿ¢»¦ÿ¼»¦£¦³¬¦§ÿ²³ÿ¬Ã¦ÿѵ¥»¦£¨ÿ ©¦£¦ÿ¢³¢½¶£¦£ÿ¡¦»¦ÿ¢½£­ÿ¼¦»®­»¾¦§ÿ®­»ÿ¬Ã¦ÿ²³É¥¦³Ð¢ÿ´¢««²³¦ÿ »¦£¼­³£¦ÿ²³ÿ£¦¢£­³ÿÌÒÇÒÍÌÒÇÇÿ®­»ÿÓÇÔǼ§¾ÿ¢³§ÿÓÕǪ̂ÿ Öÿ´¢½¥¦£ÿ­®ÿ×Ò¨ÇÒÿ¡¦»¦ÿ«­³£²§¦»¦§ÿ¢ÿ¬»¦³§ÿ¢³§ÿ­®ÿ×Ò¨ÒØÿ¡¦»¦ÿ «­³£²§¦»¦§ÿ£²µ³²Ñ«¢³¬¨ÿÙ¢¬¢ÿ¡¦»¦ÿ¢³¢½¶Ð¦§ÿ¥£²³µÿÆÚÆÆÿ£¬¢¬²£¬²«£ÿ ÌÌÿ®­»ÿÛ²³§­¡£ÿ¸ÆÚÆÆÿÀ³«¨Âÿ¯Ã²«¢µ­ÂÿÀÜÂÿÝÆÞ¹ÿ¢³§ÿÊÿըߨÒÿ ¸Ã¬¬¼£·àà¡¡¡¨»º¼»­Ï¦«¬¨­»µà¹¨. á4*â30* 7ã!ä!'.$ä&(.&'(ÿ)åÿ.ã$ÿ*.æ#çÿ)èæ/!.&)" À³ÿ¬­¬¢½ÂÿÌééÿ²³§²´²§¥¢½£ÿ¡¦»¦ÿ´¢««²³¢¬¦§ÿ¡²¬Ãÿ¬Ã¦ÿ¼¢³§¦¾²«ÿ. ²³É¥¦³Ð¢ÿ´¢««²³¦ÿ²³ÿ¬Ã¦ÿ¼¢³§¦¾²«ÿ£¦¢£­³ÿ¸êëìíîïÿñ¹¨ÿ¯°±º £¦»­£¬¢¬¥£ÿ¡¢£ÿ§¦¬¦»¾²³¦§ÿ¢³§ÿÌØÿ²³§²´²§¥¢½£ÿ¡²¬Ãÿ¢³ÿ¦ò¥²´­«¢½ÿ ¯°±ÿ£¬¢¬¥£ÿ¡¦»¦ÿ¦Ä«½¥§¦§ÿ®»­¾ÿ®¥»¬Ã¦»ÿ¢³¢½¶£²£¨ÿó®ÿ¬Ã¦ÿ»¦¾¢²³º ²³µÿÌôÕÿ²³§²´²§¥¢½£ÂÿÇÎÇÿ¡¦»¦ÿ¯°±º£¦»­¼­£²¬²´¦ÿ¸ôØõ¹¨ÿÁ»­¥¼£ÿ ­®ÿ¯°±º£¦»­¼­£²¬²´¦ÿ¢³§ÿ¯°±º£¦»­³¦µ¢¬²´¦ÿ²³§²´²§¥¢½£ÿ¡¦»¦ÿ «­¾¼¢»¢¿½¦ÿ®­»ÿ£¦ÄÂÿ¢µ¦Âÿ¢³§ÿ¼»¦´²­¥£ÿ²³É¥¦³Ð¢ÿ´¢««²³¢¬²­³£ÿ ¸ö÷øùïÿñ¹¨ÿÀ³ÿ£¦¢£­³ÿÌÒÇÒÍÌÒÇÇÂÿÇÌéÿ­®ÿ¬Ã¦ÿÌôÕÿ¼¢»¬²«²¼¢³¬£ÿ¡¦»¦ÿ ´¢««²³¢¬¦§ÿ¡²¬Ãÿ¬Ã¦ÿ£¦¢£­³¢½ÿ´¢««²³¢¬²­³ÿ­®ÿ¡Ã²«ÃÿÎôÿ¸Øú¨ßõ¹ÿ ¡¦»¦ÿ¯°±º£¦»­¼­£²¬²´¦¨ÿÞ½£­Âÿ²³ÿ¬Ã¦ÿ£¥¿£¦ò¥¦³¬ÿ£¦¢£­³Âÿ³­ÿ§²®º ®¦»¦³«¦£ÿ²³ÿ£¦ÄÂÿ¢µ¦Âÿ¢³§ÿ¼»¦´²­¥£ÿ²³É¥¦³Ð¢ÿ´¢««²³¢¬²­³£ÿ¿¦¬¡¦¦³ÿ ¯°±º£¦»­¼­£²¬²´¦ÿ¢³§ÿ¯°±º£¦»­³¦µ¢¬²´¦ÿ²³§²´²§¥¢½£ÿ¡¦»¦ÿ ­¿£¦»´¦§ÿ¸ö÷øùïÿñ¹¨. û$>!.&ü$ÿ4åå$'.ÿ)åÿ1>$ÿ)"ÿý"þæ$"ÿ!ÿ0&.$ä(ÿ !å.$äÿ01ÿ3454ÿ!"#$%&'ÿý"þæ$"ÿ!ÿ 9Û¦!ÿ'²³'´¦&"£¬²!µ¢.¬&¦)" §ÿ²®ÿ¬Ã¦»¦ÿ¡¢£ÿ¢³ÿ¦ª¦«¬ÿ­®ÿ¢µ¦ÿ­³ÿ¬Ã¦ÿ²³§¥«¬²­³ÿ­®ÿ. ¢³¬²¿­§²¦£ÿ¬­ÿ¬Ã¦ÿ¼¢³§¦¾²«ÿ²³É¥¦³Ð¢ÿ´¢««²³¢¬²­³ÿ²³ÿ­¥»ÿ£¬¥§¶ÿ ¼­¼¥½¢¬²­³¨ÿÞ6¦»ÿ¼¢³§¦¾²«ÿ´¢««²³¢¬²­³ÂÿÓÇÔǼ§¾ÿ²³É¥¦³Ð¢ÿ ´²»¥£º£¼¦«²Ñ«ÿ¢³¬²¿­§¶ÿ¬²¬¦»£ÿ¡¦»¦ÿ³¦µ¢¬²´¦½¶ÿ«­»»¦½¢¬¦§ÿ¡²¬Ãÿ¢µ¦ÿ ¢¬ÿ¢½½ÿ¬²¾¦ÿ¼­²³¬£ÿ¼­£¬º´¢««²³¢¬²­³ÿ¦Ä«¦¼¬ÿÅØÿ¸£¦¦ÿÅ¢¿½¦ÿÆéÿ²³ÿ Æ¥¼¼½¦¾¦³¬¢»¶ÿ°¢¬¦»²¢½¹¨ÿʦ¼»¦£¦³¬¢¬²´¦ÿ§¢¬¢ÿ¢»¦ÿ§¦¼²«¬¦§ÿ®­»ÿÅÌÿ ²³ÿêëìíîïÿ78ÿ¸ÅÌÂÿ9ÿPÿÒ¨ÒÒÇÕÂÿ ÿPÿ

(41) Ò¨Çú鹨ÿÀ³§²´²§¥¢½£ÿ¢»¦ÿ§²´²§¦§ÿ ²³¬­ÿ¬Ã»¦¦ÿ¢µ¦ÿµ»­¥¼£ÿ®­»ÿ®¥»¬Ã¦»ÿ¢³¢½¶£²£ÿ¿¶ÿ¢¼¼»­Ä²¾¢¬¦½¶ÿÇÒº¶¦¢»ÿ ²³¬¦»´¢½£¨ÿƲµ³²Ñ«¢³¬ÿ§²ª¦»¦³«¦£ÿ¡¦»¦ÿ¢½£­ÿ­¿£¦»´¦§ÿ¿¦¬¡¦¦³ÿ¢µ¦ÿ µ»­¥¼£ÿ²³ÿ¬Ã¦ÿÓÇÔǼ§¾ÿ¬²¬¦»£ÿ¸¦¨µ¨ÂÿÅÌÂÿ9ÿPÿÒ¨ÒÇô¹Âÿ¡²¬Ãÿ½­¡¦»ÿ »¦£¼­³£¦£ÿ²³ÿ¬Ã¦ÿ­½§¦£¬ÿ¢µ¦ÿµ»­¥¼ÿ«­¾¼¢»¦§ÿ¬­ÿ¬Ã¦ÿ¶­¥³µ¦£¬ÿ ¬¡­ÿ¢µ¦ÿµ»­¥¼£ÿ¸¦¨µ¨ÂÿÅÌÂÿÇúÍÕÒÿ´¦»£¥£ÿßÒÍØÌÿ¶¦¢»ÿ9ÿPÿÒ¨ÒÒιÿ ¸êëìíîïÿ7 ¹ÿ¸£¦¦ÿÅ¢¿½¦ÿÆéÿ²³ÿÆ¥¼¼½¦¾¦³¬¢»¶ÿ°¢¬¦»²¢½¹¨ÿƲ¾²½¢»ÿ »¦£¥½¬£ÿ¡¦»¦ÿ­¿£¦»´¦§ÿ®­»ÿ¬Ã¦ÿ§²ª¦»¦³¬ÿ¢µ¦ÿµ»­¥¼£ÿ¡Ã¦³ÿ¢³¢½¶Ð²³µÿ ¬Ã¦ÿ§¢¬¢ÿ¿¶ÿ¼»­¬¦«¬²­³ÿ½¦´¦½Âÿ§¦Ñ³¦§ÿ¿¶ÿ»¦¢«Ã²³µÿ¢ÿ¬²¬¦»ÿ­®ÿßÒÿ ÓÞÝÿ¸§¢¬¢ÿ³­¬ÿ£Ã­¡³¹¨ÿ©¦£¦ÿ§¢¬¢ÿ²³§²«¢¬¦ÿ¬Ã¢¬ÿ¬Ã¦»¦ÿ¢»¦ÿ¢½»¦¢§¶ÿ £²µ³£ÿ­®ÿ²¾¾¥³­£¦³¦£«¦³«¦º§»²´¦³ÿ²¾¼¢²»¦§ÿ´¢««²³¦ÿ»¦£¼­³£¦£ÿ ¬­ÿ¢ÿ³­´¦½ÿ¢³¬²µ¦³ÿ«Ã¢½½¦³µ¦ÿ²³ÿ¾²§§½¦º¢µ¦§ÿ²³§²´²§¥¢½£¨. û)ÿ4åå$'.ÿ)åÿ789*$ä)è)(&.&ü&.çÿ)"ÿ 1".&)#çÿ0&.$ä(ÿ!å.$äÿ!"#$%&'ÿý"þæ$"ÿ!ÿ 9Ô¦!Ä'¬Âÿ'¬Ã&"¦ÿ!¦ª.¦&«)" ¬ÿ­®ÿ½¢¬¦³¬ÿ¯°±ÿ²³®¦«¬²­³ÿ­³ÿ¬Ã¦ÿ²³É¥¦³Ð¢ÿ´²»¥£ºÿ. £¼¦«²Ñ«ÿ¢³¬²¿­§¶ÿ»¦£¼­³£¦ÿ¬­ÿ¬Ã¦ÿ´¢««²³¦ÿ¡²¬Ãÿ¬Ã¦ÿ³¦¡½¶ÿ²³¬»­º §¥«¦§ÿÓÇÔǼ§¾ÿ²³É¥¦³Ð¢ÿ´¢««²³¦ÿ£¬»¢²³ÿ¡¢£ÿ²³´¦£¬²µ¢¬¦§¨ÿ ¯°±º£¦»­¼­£²¬²´¦ÿ²³§²´²§¥¢½£ÿ¡¦»¦ÿ«­¾¼¢»¦§ÿ¬­ÿ¯°±º £¦»­³¦µ¢¬²´¦ÿ²³§²´²§¥¢½£ÿ®­»ÿ²³É¥¦³Ð¢ÿ¬²¬¦»£ÿ¿¦®­»¦ÿ¢³§ÿ¢6¦»ÿ ´¢««²³¢¬²­³¨ÿÔ­ÿ§²ª¦»¦³«¦£ÿ¿¦¬¡¦¦³ÿ¯°±º£¦»­¼­£²¬²´¦ÿ¢³§ÿ ¯°±º£¦»­³¦µ¢¬²´¦ÿ²³§²´²§¥¢½£ÿ²³ÿ²³É¥¦³Ð¢ÿ¬²¬¦»ÿ¢¬ÿ¢³¶ÿ¬²¾¦ÿ ¼­²³¬ÿ²³ÿ¿­¬Ãÿ£¦¢£­³£ÿ¡¦»¦ÿ®­¥³§ÿ¸²µ¥»¦ÿÆÇÞÿ²³ÿÆ¥¼¼½¦¾¦³¬¢»¶ÿ °¢¬¦»²¢½¹¨ÿÆ­¾¦ÿ²³§²´²§¥¢½£ÿ§²§ÿ¢½»¦¢§¶ÿ£Ã­¡ÿ¢ÿ§¦¬¦«¬¢¿½¦ÿ¼¢³º §¦¾²«ÿ¬²¬¦»ÿ¿¦®­»¦ÿ´¢««²³¢¬²­³Âÿ¢½¬Ã­¥µÃÿ­³ÿ¢´¦»¢µ¦ÿ¬Ã¦ÿ¼»¦º¬²¬¦»ÿ ¡¢£ÿ´¦»¶ÿ½­¡ÿ¸Á°Åÿú¨ßÿÓÞݹ¨ÿÅ­ÿ«­»»¦«¬ÿ®­»ÿ¬Ã²£ÿ¢³§ÿ­¬Ã¦»ÿ ¼­¬¦³¬²¢½ÿ«­³®­¥³§¦»£Âÿ²³É¥¦³Ð¢ÿ¬²¬¦»£ÿ­®ÿ¯°±º£¦»­¼­£²¬²´¦ÿ ¢³§ÿ¯°±º£¦»­³¦µ¢¬²´¦ÿ²³§²´²§¥¢½£ÿ¡¦»¦ÿ¢³¢½¶Ð¦§ÿ¢§Ï¥£¬¦§ÿ®­»ÿ ¼»¦º¬²¬¦»Âÿ£¦ÄÂÿ¢µ¦Âÿ¢³§ÿ¼»¦´²­¥£ÿ²³É¥¦³Ð¢ÿ´¢««²³¢¬²­³£ÿ¡²¬Ãÿ¢ÿ ÁËËÿ¾­§¦½ÿ¸Å¢¿½¦ÿÆÌÿ²³ÿÆ¥¼¼½¦¾¦³¬¢»¶ÿ°¢¬¦»²¢½¹¨ÿÔ­ÿ£²µ³²Ñ«¢³¬ÿ. 01234ÿ6ÿ8ÿ9

(42) 

(43)  ÿÿÿ ÿ

(44) ÿ  ÿ ÿ ÿ ÿ !"#$%&'ÿ($!()" 0).!/ÿ 789:ÿ 789<ÿ *&>"&?'!"'$ 01ÿ3ÿ+456! 01ÿ3ÿ6;66 01ÿ3ÿ=+6 HIIÿDJKG HIHÿDKLG HIMÿDKMG NÿPÿKK BCÿD ÿ ÿEFG ERÿDSÿG QMS MS QS NÿPÿI QIS QIJS QJKS NÿPÿK T

(45) UÿVW ÿU  ÿX

(46) ÿÿ   ÿ  HQS HIS NÿPÿ E  ÿU  ÿIÿX

(47) ÿ HLS HKS HMIS NÿPÿJI E  ÿU  ÿIÿ

(48) Cÿ HJHS. *$!()"ÿ+,6,-+,66 0).!/ÿ 789:ÿ 789<ÿ 01ÿ3ÿ6+@6 01ÿ3ÿ;46 01ÿ3ÿA+6 QHÿDKG QJÿDJJG QLHÿDKLG QKQS QLS MIS LMLS LHS LIS KJSX JJLS JKKS. *&>"&?'!"'$ NÿPÿQH NÿPÿMI NÿPÿMJ NÿPÿ. YZ[\]^_`a\bcdefÿhYijklf^d\m\fc[cb^ÿ`noÿYijlf^d\n^_`[cb^ÿ_d\emÿ`d^ÿp\]m`d^oÿqc[rÿs[eo^n[tfÿ[l[^f[ÿu\dÿ`_^ÿ`noÿqc[rÿ[r^ÿvcfpr^dÿ^w`p[ÿ[^f[ÿu\dÿp`[^_\dcp`aÿb`dc`xa^fy `zc ]^ÿm\cn[ÿ{|ÿ{}ÿq^^fÿ`u[^dÿm`no^]cpÿcn€e^n`ÿb`ppcn`[c\n|ÿxa\\oÿq`fÿp\a^p[^oÿ\uÿ‚{{ÿm`d[cpcm`n[fÿqr\ÿp\n[cne^oÿcnÿ[r^ÿf[eoZÿu\dÿf^`f\nÿ}ƒ‚ƒ„}ƒ‚‚y xs^`f\n`a ÿb`ppcn`[c\nÿcnÿ}ƒƒ ÿx^u\d^ÿf[eoZÿ\dÿoedcn_ÿf[eoZÿp\]xcn^oy. œ

(49) 

(50) ÿÿCÿ8ÿžžž

(51) 

(52) 

(53) C. †. Ÿ 

(54) ÿKÿ8ÿ ÿIÿ8ÿB

(55)  ÿK.

(56) ÿ

(57) ÿF

(58) ÿ

(59) ÿ&. GHIÿKLLMNOÿPQRSMTUNÿVRWXMRYQÿIQNNURQOUZR. `abcdecfbgÿaicdÿjikÿblkdamdnoÿpbjdmdaqÿrstukdab`bkfcfmfcvÿjikÿ ikkbeficdnÿjfcwÿdgwigednÿxÿzbgcwkÿignÿ{ÿvdiaÿ`abcdecfbgÿaicdkÿ i|daÿ`igndzfeÿmieefgicfbgoÿ}dÿ`daedgci~dÿfg€dgiÿ`abcdecdnÿ fgnfmfn€i‚kÿfkÿkf~gfƒeigc‚vÿwf~wdaÿ„baÿrstukdab`bkfcfmdÿfgnfu mfn€i‚kÿcwigÿ„baÿrstukdabgd~icfmdÿfgnfmfn€i‚kqÿlbcwÿ xÿjdd†kÿ ‡ˆÿ7ÿ‰o‰Š‹Œÿignÿ ÿjdd†kÿ‡ˆÿ7ÿ‰o‰ŠŠŒÿi|daÿ`igndzfeÿmieefgicfbgÿ ‡Ž‘’“ÿ•–Œÿ‡€gin—€kcdnÿniciÿfgÿ˜f~€adÿ™{šÿfgÿ™€``‚dzdgciavÿ sicdafi‚Œoÿ›b~dcwdaqÿcwfkÿk€~~dkckÿcwicÿ‚icdgcÿrstÿfg„decfbgÿnfnÿ gbcÿfz`ifaÿcwdÿ`abcdecfbgÿaicdÿi|daÿfg€dgiÿmieefgicfbgqÿl€cÿf„ÿ igvcwfg~qÿzf~wcÿldÿldgdƒefi‚ÿ„baÿ`dakfkcdgedÿb„ÿ`abcdecfbgÿi|daÿ cwdÿœÿŸ ¡ ÿfg€dgiÿmieefgicfbgo. ¢£¤¥ÿ,¦§£¨©ª«ÿ1¤2ÿ¬­®­¯°ÿ,°ÿ±²³³´¤µ§­ÿ ªµ³¶­³ÿ´·ÿ©ª«ÿ4­µ¸§£®µ§£´¦ÿ,³­ÿ¹´§ÿ ,°°´¸£µ§­ºÿ»£§¥ÿ1¼½µ£³­ºÿ¾µ¦º­¼£¸ÿ 1¦¿²­¦Àµÿ«µ¸¸£¦­ÿ4­°½´¦°­ÿ£¦ÿÿ ©ª« ¨±­³´½´°£§£®­ÿ1¦º£®£º²µ¯° ›bÿkc€nvÿfgÿcwdÿrstukdab`bkfcfmdÿfgnfmfn€i‚kÿjwdcwdaÿcwdÿ. „adÁ€dgevÿb„ÿrstÿadiecfmicfbgÿwikÿiÿgd~icfmdÿdÂdecÿbgÿcwdÿ fg€dgiÿigcflbnvÿadk`bgkdkqÿigcfurstÿÃ~Äÿ‚dmd‚kÿjdadÿ€kdnÿikÿ iÿk€aab~icdÿzia†daÿb„ÿrstÿadiecfmicfbgÿ‡ qÿŠ Œÿignÿikkbeficdnÿ jfcwÿcwdÿfg€dgiÿigcflbnvÿadk`bgkdÿcbÿmieefgicfbgoÿ›bÿcwfkÿdgnqÿ rstukdab`bkfcfmdÿfgnfmfn€i‚kÿjfcwÿ‚bjÿigcfurstÿÃ~Äÿ‚dmd‚kÿ ‡ÅƉÿÇÈz‚Œqÿzdnf€zÿigcfurstÿÃ~Äÿ‚dmd‚kÿ‡ÉƉÿÇÈz‚qÿÅʉÿ ÇÈz‚Œÿbaÿwf~wÿigcfurstÿÃ~Äÿ‚dmd‚kÿ‡ÉʉÿÇÈz‚Œÿjdadÿebz`iadnÿ „baÿcwdfaÿfg€dgiÿigcflbnvÿcfcdaÿignÿ`abcdecfbgÿaicdÿlbcwÿ€ginu —€kcdnÿ‡˜f~€adkÿ™{rqËÿfgÿ™€``‚dzdgciavÿsicdafi‚Œÿignÿjfcwÿcwdÿ ÄÌÌÿzbnd‚ÿ‡›il‚dÿ™Æÿfgÿ™€``‚dzdgciavÿsicdafi‚ŒoÿÍbÿnfÂdadgedkÿ jdadÿblkdamdnÿldcjddgÿigcfurstÿÃ~Äÿ~ab€`kÿfgÿcwdÿp{Í{`nzÿ fg€dgiÿcfcdakÿbaÿ`abcdecfbgÿaicdÿi|daÿcwdÿ`igndzfeÿmieefgiu cfbgÿ‡Ž‘’“Îÿ•ÏÐьoÿ}fkÿfgnfeicdkÿcwicÿndk`fcdÿiÿgd~icfmdÿdÂdecÿ b„ÿi~dÿbgÿcwdÿigcflbnvÿadk`bgkdÿcbÿcwdÿ`igndzfeÿmieefgicfbgÿ ‡Ž‘’“ÿҌqÿgbÿkf~gkÿb„ÿfz`ifazdgcÿlvÿrstÿadiecfmicfbgÿjdadÿ blkdamdnoÿӂkbÿcwfkÿkwbjkÿcwicÿcwdÿ`bkfcfmdÿdÂdecÿb„ÿrstÿkcic€kÿ bgÿ‚bg~ucdazÿ`abcdecfbgÿi|daÿ`igndzfeÿfg€dgiÿmieefgicfbgÿ ‡Ž‘’“ÿ•–Œÿeb€‚nÿgbcÿldÿdÔ`‚ifgdnÿlvÿnfÂdadgedkÿfgÿigcfurstÿ Ã~Äÿ~ab€`kÿjfcwfgÿrstukdab`bkfcfmdÿfgnfmfn€i‚ko. 012345ÿ7ÿ8ÿ

(60) ÿ ÿ

(61) ÿÿ

(62) ÿ

(63)  ÿÿ

(64) ÿ 

(65) ÿ 

(66) ÿ ÿ!ÿ

(67) 

(68) 

(69) 

(70) ÿ

(71) ÿ ÿ

(72) ÿ"#$#%ÿÿ 

(73) ÿ 

(74) ÿ

(75) % ÿ ÿ&

(76) ÿÿ

(77) ÿ'()*ÿ+,-ÿ.

(78) ÿ /&ÿ&

(79) ÿ

(80) 

(81) 

(82) ÿÿ

(83) 

(84) ÿ

(85) ÿ

(86) ÿ ÿ01ÿ/

(87) %&ÿÿ ÿ'"!2*ÿ(/

(88) ÿ

(89) %

(90)  ÿ%

(91) ÿ ÿ/

(92) ÿ

(93) ÿÿ

(94) ÿ+3-ÿ 

(95) ÿ  ÿÿ

(96) ÿ ÿ

(97) 

(98) ÿ

(99) ÿÿ 

(100) ÿ ÿ4/ÿ"#$#%ÿ ÿ()ÿ'5ÿ7ÿ11#8ÿ!$9:!*ÿ;

(101) &ÿ

(102) ÿ

(103) 

(104) ÿ4/ÿ<

(105) ÿ 

(106) &ÿ .

(107) 

(108) 

(109) ÿ

(110) 4

(111)

(112) ÿ4ÿ

(113) ÿÿ

(114) ÿ

(115) 

(116) ÿ4/ÿ=

(117) >ÿ?

(118) ÿ ÿ & %

(119) ÿ

(120) ÿÿ

(121) ÿ@@5ÿAÿ11#1ÿBC(Dÿ

(122) %

(123)  ÿÿ %

(124) ÿ

(125) . nfÂdadgedkÿjdadÿ„b€gnÿldcjddgÿrstukdab`bkfcfmdÿignÿrstu kdabgd~icfmdÿfgnfmfn€i‚kÿfgÿigcflbnvÿcfcdakÿicÿdiewÿfgnfmfn€i‚ÿ cfzdÿ`bfgcÿ‡Ž‘’“ÿ•ÚŒoÿ™bÿi‚cwb€~wÿi~dÿkwbjkÿiÿgd~icfmdÿdÂdecÿ bgÿcwdÿgbmd‚ÿ`igndzfeÿp{Í{`nzÿigcflbnvÿadk`bgkdÿfgnfeicfmdÿ b„ÿfzz€gbkdgdkedgedÿcbÿœÿŸ ¡ ÿadk`bgkdÿ‡Ž‘’“ÿҌqÿgbÿdÂdecÿ b„ÿrstukdabkcic€kÿbgÿcwdÿfg€dgiÿmfa€kÿcfcdaÿfkÿblkdamdnÿi|daÿ `igndzfeÿmieefgicfbgÿfgÿin€‚ckÿ‡Ž‘’“ÿ•ÚŒo. ¢£¤¥­³ÿ4­°£º²µ¯ÿ¾³´§­¸§£´¦ÿ4µ§­°ÿµ·§­³ÿ ¾µ¦º­¼£¸ÿ1¦¿²­¦Àµÿ«µ¸¸£¦µ§£´¦ÿ£¦ÿÿ ©ª«¨±­³´½´°£§£®­ÿ1¦º£®£º²µ¯°ÿ§¥µ¦ÿÿ £™¦€lÿ©ª« ¨±­³´¦­¤µ§£®­ÿ1¦º£®£º²µ¯° kdÁ€dgc‚vqÿjdÿfgmdkcf~icdnÿjwdcwdaÿcwdadÿjikÿigÿdÂdecÿb„ÿ. rstukdabkcic€kÿbgÿcwdÿ`abcdecfbgÿaicdqÿikÿndƒgdnÿlvÿigcflbnvÿ cfcdaÿ݊‰ÿpÓÇqÿi~ifgkcÿfg€dgiÿmfa€kÿi|daÿfg€dgiÿmieefgicfbgÿ ‡Š{Œoÿ™wbac‚vÿi|daÿmieefgicfbgqÿgbÿdÂdecÿb„ÿrstukdabkcic€kÿbgÿcwdÿ [

(126) ÿÿ\%%&ÿ8ÿ444 

(127) . E. ¹´ÿ5··­¸§ÿ´·ÿ,¤­ÿ´³ÿ©ª«¨±­³´°§µ§²°ÿÿ ´¦ÿ±­µ°´¦µ¯ÿ1¦¿²­¦Àµÿ«µ¸¸£¦µ§£´¦ÿÿ »£ §¥ÿ¢Õ¹Õ½º¼ÿµ¦ºÿ¢Ö¹7 }dÿkizdÿigi‚vkdkÿ„baÿcwdÿdÂdecÿb„ÿi~dÿignÿ‚icdgcÿrstÿfg„decfbgÿ. bgÿfg€dgiÿmieefgicfbgÿjdadÿ`da„bazdnÿ„baÿcwdÿ{ ×ÿfgnfmfn€i‚kÿ cwicÿebgcfg€dnÿjfcwÿcwdÿkc€nvÿignÿjdadÿmieefgicdnÿfgÿkdikbgÿ ‰{‰Ø ‰{{ÿjfcwÿcwdÿkdikbgi‚ÿfg€dgiÿmieefgicfbgÿebgcifgfg~ÿ cwdÿkizdÿp{Í{`nzÿkcaifgÿignÿigÿpÆÍ ÿkcaifgoÿÓÿcadgnÿb„ÿiÿ gd~icfmdÿdÂdecÿb„ÿi~dÿbgÿcwdÿp{Í{`nzÿzdzbavÿadk`bgkdÿjikÿ blkdamdnqÿl€cÿgbÿkf~gfƒeigcÿnfÂdadgedkÿfgÿigcflbnvÿcfcdakÿ„baÿ p{Í{`nzÿbaÿpÆÍ ÿjdadÿ„b€gnÿldcjddgÿi~dÿ~ab€`kÿicÿigvÿ cfzdÿ`bfgcÿi|daÿmieefgicfbgÿfgÿkdikbgÿ ‰{‰Ø ‰{{ÿ‡do~oqÿ› qÿ adk`decfmd‚vqÿˆÿ7ÿ‰o{‰{ÿignÿˆÿ7ÿ‰oŠÆŠŒÿ‡Ž‘’“ÿÙڌoÿšbcwÿcwdÿ fg€dgiÿigcflbnvÿcfcdaÿignÿcwdÿ`abcdecfbgÿaicdÿnfnÿgbcÿnfÂdaÿ ldcjddgÿrstukdab`bkfcfmdÿignÿrstukdabgd~icfmdÿfgnfmfn€i‚kÿ ‡Ž‘’“ÎÿٖÛÑÜÿ›il‚dkÿ™Šÿignÿ™xÿfgÿ™€``‚dzdgciavÿsicdafi‚Œoÿ ™€a`afkfg~‚vqÿfg€dgiÿigcflbnvÿcfcdakÿignÿ`abcdecfbgÿaicdÿi|daÿcwdÿ ]ÿ)1#^ÿ8ÿ:&%

(128) ÿ_ÿ8ÿ! &

(129) ÿ^).

(130) ÿ&

(131) ÿL

(132) ÿ

(133) ÿ'. MNOÿQRRSTUÿVWXYSZ[Tÿ\X]^SX_WÿOWTT[XWU[`X. 012345ÿ7ÿ8ÿ

(134) ÿ ÿ

(135) ÿ 

(136) ÿÿ

(137) ÿÿ

(138) !ÿ"#

(139) $ ÿ%&ÿ

(140) ÿ&ÿ#

Referenties

GERELATEERDE DOCUMENTEN

Uit de praktijkvoorbeelden in Aalst en Eindhoven blijkt dat deze partijen in de huidige situatie voornamelijk zijn gericht op het vergroten van het eigen

Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of

To this end, we describe the results from three attempted direct replications of a protection effect experiment reported in Tykocinski (2008) and two replications of a tempting

convinced of the benefit of exchanging the information, or are directly opposed to sharing it. However, the ENUs cannot openly state this, as they are required by European

Chapter 4 examines the strategic narratives on the United Nations as presented by Annan and Bush at the 2005 World Summit, whereas chapter 5 considers the narrative from World War

Therefore, both variables seem to cause respondents to assess the accuracy of the news items more thoroughly, as individuals who have received items with a warning or with an

It was recently demonstrated that T-helper cell polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters ( 31 ) Because prime

A system calibration and data processing method has been set up to provide spatial information on temperature and a spatially accurate radiant intensity map