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UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)

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Kidney oxygenation under pressure

van der Bel, R.

Publication date

2017

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Other version

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Citation for published version (APA):

van der Bel, R. (2017). Kidney oxygenation under pressure.

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kidne

y o

xy

ge

na

tion

under pr

essur

e

Kidney oxygenation

under pressure

René van der Bel

UITNODIGING

Voor het bijwonen van de

openbare verdediging van

mijn proefschrift

KIDNey OxyGeNaTION

under pressure

Vrijdag 15 december 2017

om 11:00 uur

aULa

Universiteit van amsterdam

Singel 411 te amsterdam

aansluitend receptie

René van der Bel

Paranimfen:

guido Bakker

Hessel Peters Sengers

© R van der Bel 2017

René v

an der Bel

kidne

y o

xy

ge

na

tion

under pr

essur

e

Kidney oxygenation

under pressure

René van der Bel

UITNODIGING

Voor het bijwonen van de

openbare verdediging van

mijn proefschrift

KIDNey OxyGeNaTION

under pressure

Vrijdag 15 december 2017

om 11:00 uur

aULa

Universiteit van amsterdam

Singel 411 te amsterdam

aansluitend receptie

René van der Bel

Paranimfen:

guido Bakker

Hessel Peters Sengers

© R van der Bel 2017

René v

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Kidney oxygenation under pressure

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Kidney oxygenation under pressure

PhD Thesis, University of Amsterdam, The Netherlands ISBN: 978-94-6299-737-0 Online: http://dare.uva.nl Copyright © 2017 René van der Bel, Amsterdam, The Netherlands. All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author. Cover design: René van der Bel Lay-out photography: René van der Bel Layout by: Ridderprint BV - www.ridderprint.nl Printed by: Ridderprint BV - www.ridderprint.nl The studies presented in this thesis have been prepared and conducted at the Department of Internal Medicine, Divisions of Nephrology and Vascular Medicine and at the Depart-ments of Radiology, Nuclear Medicine and Hyperbaric Medicine, Academic Medical Center, University of Amsterdam, The Netherlands. The research described in this thesis was financially supported by the Dutch Kidney Foun-dation (Kolff grant KJPB12.029) and the Netherlands Organization for Health Research and Development (ZonMw, Clinical Fellowship 40007039712461). Financial support by the Dutch Heart Foundation and the Stichting tot Steun Promovendi Vasculaire Geneeskunde for the publication of this thesis is gratefully acknowledged. Publication of this thesis was financially supported by the University of Amsterdam, Finapres Medical Systems, Pfizer, ChipSoft, Bayer, Sanofi

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Kidney oxygenation under pressure

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit op vrijdag 15 december 2017, te 11.00 uur door

René van der Bel geboren te Rotterdam

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Promotiecommissie

Promotores: Prof. dr. E.S.G. Stroes AMC-UvA Prof. dr. J.J. Homan van der Heide AMC-UvA Copromotores: Dr. C.T.P. Krediet AMC-UvA Dr. ir. A.J. Nederveen AMC-UvA Overige leden: Prof. dr. J.A. Reekers AMC-UvA Prof. dr. J.J. van Lieshout University of Nottingham Prof. dr. K.J. Jager AMC-UvA Dr. M. Pruijm University Hospital of Lausanne Dr. P.J. Blankestijn Universitair Medisch Centrum Utrecht Prof. dr. E.T. van Bavel AMC-UvA Faculteit der Geneeskunde

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table of contents

Chapter 1 Introduction and thesis outline 7 Chapter 2 Cross-correlation baroreflex sensitivity and its association with cardiovascular risk in a large multi-ethnic population 23 Chapter 3 Part A Blood pressure increase during oxygen supplementation in chronic kidney disease patients is mediated by vasoconstriction independent of baroreflex function 39 Part B A modified device for continuous non-invasive blood pressure measurements in humans under hyperbaric and/or oxygen-enriched conditions 55 Chapter 4 Magnetic resonance imaging derived renal oxygenation and perfusion during continuous, steady-state angiotensin-II infusion in healthy humans 67 Chapter 5 Sympathetic activation by lower body negative pressure decreases kidney perfusion without parallel reduction in oxygenation in healthy humans 85 Chapter 6 A tri-exponential model for intravoxel incoherent motion analysis of the human kidney: in silico and during pharmacological renal perfusion modulation 99 Chapter 7 General discussion and perspectives 117 Appendices Supplementary documents 129 Summary 131 Samenvatting (Dutch summary) 137 List of publications 143 Portfolio 145 Dankwoord (acknowledgements) 147 Curriculum Vitae 151

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