123I-mIBG assessed cardiac sympathetic activity: standardizing towards clinical implementation - Front matter

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123I-mIBG assessed cardiac sympathetic activity: standardizing towards clinical

implementation

Verschure, D.O.

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2017

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Verschure, D. O. (2017). 123I-mIBG assessed cardiac sympathetic activity: standardizing

towards clinical implementation.

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12 3 I-m IB G a sse sse d c ardia c s ym pat he tic a cti vi ty: s ta nd ardi zin g t ow ard s c lin ica l im ple m en tat io n D erk O tto V ers ch ure

123

I-mIBG assessed

cardiac sympathetic activity:

standardizing towards

clinical implementation

Derk Otto Verschure

Uitnodiging

Voor het bijwonen van de openbare verdediging

van het proefschrift 123

_{I-mIBG assessed}

cardiac sympathetic activity:

standardizing towards

clinical implementation

door Derk Otto Verschure

28 maart 2017 om 14:00 uur Aansluitend receptie Amsterdamse Academische Club

Oudezijds Achterburgwal 235 Amsterdam Derk Verschure Koninginneweg 48-2 1075EA Amsterdam d.o.verschure@amc.uva.nl 06-24631101 Paranimfen

Diederik van Wijk dfvanwijk@gmail.com

Michiel Peters mhvpeters@hotmail.com

Derk Otto Verschure

123

_{I-mIBG assessed cardiac sympathetic activity:}

Processed on: 20-2-2017 Processed on: 20-2-2017 Processed on: 20-2-2017 Processed on: 20-2-2017 508097-L-bw-Verschure 508097-L-bw-Verschure 508097-L-bw-Verschure 508097-L-bw-Verschure

123_{I-mIBG assessed cardiac sympathetic activity:}

standardizing towards clinical implementation

PhD thesis, University of Amsterdam, the Netherlands ISBN: 978-94-028-0501-7

Online: http://dare.uva.nl

© 2017 Derk Otto Verschure, Amsterdam, The Netherlands

All rights reserved. No part of this publication may be reproduced, stored of transmitted in any forms of by any means without written permission of the author.

Cover illustration: Steffie Padmos. www.steffiepadmos.com Lay-out: Lyanne Tonk. www.persoonlijkproefschrift.nl Printing: Ipskamp Printing BV, Enschede, the Netherlands

An ancillary research grant from GE Healthcare is gratefully acknowledged.

Financial support for publication of the thesis was kindly provided by: HERMES Medical Solutions, Sanofi, Boehringer Ingelheim.

123

_{I-mIBG assessed cardiac sympathetic activity:}

standardizing towards clinical implementation

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor

Promoties ingestelde commissie,

in het openbaar te verdedigen in de Agnietenkapel

op dinsdag 28 maart 2017, te 14:00 uur

door

Derk Otto Verschure

geboren te Schiedam

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PROMOTIECOMMISSIE

Promotor: Prof. dr. B.L.F. van Eck-Smit Universiteit van Amsterdam

Copromotores: Dr. H.J. Verberne Universiteit van Amsterdam

Dr. G.A. Somsen Cardiologie Centra Nederland

Overige leden: Prof. dr. K. Nakajima Kanazawa University Prof. dr. J. Booij Universiteit van Amsterdam Prof. dr. J.J. Piek Universiteit van Amsterdam Dr. J.R. de Groot Academisch Medisch Centrum Prof. dr. J.F. Verzijlbergen Radboud Universiteit Nijmegen Dr. A.J.H.A. Scholte Universiteit Leiden

Faculteit: Geneeskunde

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

Ter herinnering aan mama

Voor Saar, Olivier en Stijn

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LIST OF ABBREVIATIONS

ACE-I angiotensin converting enzyme inhibitor AMPT alpha-methyl-para-tyrosine

AR adrenergic receptor

ARB angiotensin II receptor blocker CCB calcium channel blocker CHD congenital heart disease CHF chronic heart failure

COMT catechol-O-methyl-transferase

DA dopamine

CRP C-reactive protein

e-CC estimated creatinine clearance e-GFR estimated glomerular filtration rate

HF heart failure

HR hazard ratio

H/M ratio heart-to-mediastinum ratio LVEF left ventricle ejection fraction MDRD modification of diet in renal disease

NE norepinephrine

NET norepinephrine transporter

NT-proBNP N-terminal pro B-type Natriuretic Peptide p.i. post injection

ROI region of interest

SPECT single photon emission computed tomography TCM tako-tsubo cardiomyopathy

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TABLE OF CONTENTS

Introduction and outline: the role of 123_{I-mIBG in the} assessment of cardiac sympathetic activity in patients with chronic heart failure

Netherlands Heart Journal. 2016;24:701-708.

Standardization and validation of cardiac 123_I-mIBG

scintigraphy

¹²³I-mIBG heart-to-mediastinum ratio is influenced by high-energy photon penetration of collimator septa from liver and lung activity

Nuclear Medicine Communication. 2015;36:279-85.

A European myocardial 123_{I-mIBG cross-calibration phantom} study

Journal Nuclear Cardiology. 2017. E-publication ahead of print.

Impact of a predefined mediastinal ROI on inter-observer variability of planar 123_{I-mIBG heart-to-mediastinum ratio}

Journal Nuclear Cardiology. 2014;21:605-13.

Polymorphism of SLC6A2 gene does not influence outcome of myocardial 123_{I-mIBG scintigraphy in patients with chronic} heart failure

Journal Nuclear Cardiology. 2016. E-publication ahead of print.

Vascular time-activity variation in patients undergoing 123_{I-mIBG myocardial scintigraphy: implications for} quantification of cardiac and mediastinal uptake

European Journal Nuclear Medicine and Molecular Imaging. 2011;38:1132-8.

Renal function in relation to cardiac 123_{I-mIBG scintigraphy} in patients with chronic heart failure

International Journal of Molecular Imaging. 2012:434790.

Chapter 1 PART I Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 11 27 43 57 75 89 105

125 145 163 185 199 229 227 237 PART II Chapter 8 Chapter 9 Chapter 10 Part III Chapter 11 Chapter 12 Chapter 13 Chapter 14 Appendix

Prognostic value of cardiac 123_{I-mIBG scintigraphy}

For what endpoint does myocardial 123_{I-mIBG scintigraphy} have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis

European Heart Journal Cardiovascular Imaging. 2014;15:996-1003.

Myocardial 123_{I-mIBG scintigraphy in relation to markers of} inflammation and long-term clinical outcome in patients with stable chronic heart failure

Journal Nuclear Cardiology. 2016. E-publication ahead of print.

Does cardiac 123_{I-mIBG scintigraphy predict appropriate} ICD therapy in stable chronic Heart failure patients?

Submitted for publication.

Cardiac 123_{I-mIBG scintigraphy in patients other than}

heart failure

Cardiac sympathetic activity in 22q11.2 deletion syndrome

International Journal Cardiology. 2016;212:346-51.

Tako-tsubo cardiomyopathy: how to understand possible pathophysiological mechanism and the role of 123_I-mIBG imaging

Journal Nuclear Cardiology. 2014;21:730-8.

Summary, general discussion, future perspective and conclusions

Samenvatting, algemene discussie, perspectief en conclusies

Dankwoord Curriculum Vitae Bibliography