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Host genetic effects on HIV-1 replication in macrophages

Bol, S.M.

Publication date

2011

Link to publication

Citation for published version (APA):

Bol, S. M. (2011). Host genetic effects on HIV-1 replication in macrophages.

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Contents

Chapter 1 HIV-1 and the macrophage 9

Supplement: Scope of this thesis 50

Chapter 2 Donor variation in in vitro HIV-1 susceptibility of monocyte-derived macrophages

51 Chapter 3 Genome-wide association study identifies single nucleotide

polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages

73

Chapter 4 Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages

101 Chapter 5 Single nucleotide polymorphism in gene encoding transcription

factor Prep1 is associated with HIV-1-associated dementia

129 Chapter 6 Genome-wide association study on HIV-1 susceptibility in Dutch

high-risk seronegative individuals

145

Chapter 7 General discussion 157

Appendices Summary 185 Samenvatting 189 Dankwoord 193 Curriculum Vitae 195 Publications 197 Author affiliations 199

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