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Cross-reactive neutralizing humoral immunity in HIV-1 disease: dynamics of
host-pathogen interactions
van Gils, M.J.
Publication date
2011
Link to publication
Citation for published version (APA):
van Gils, M. J. (2011). Cross-reactive neutralizing humoral immunity in HIV-1 disease:
dynamics of host-pathogen interactions.
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T
ableofconTenTsChapter 1 General introduction 9
Chapter 2 High prevalence of neutralizing activity against multiple unrelated HIV-1 subtype B variants in sera from HIV-1 subtype B infected individuals: evidence for subtype-specific rather than strain-specific neutralizing activity
23
Chapter 3 Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1 infected patients with rapid or slow disease progression
39
Chapter 4 Cross-reactive neutralizing humoral immunity does not protect from HIV-1 disease progression
57
Chapter 5 Correlations between HIV-1 clades and HIV-1 antibody neutralization sensitivity: significant for vaccine development?
77
Chapter 6 Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection
97
Chapter 7 Rapid escape from preserved cross-reactive neutralizing humoral immunity without loss of viral fitness in HIV-1 infected
progressors and long-term non-progressors
129
Chapter 8 Changing sensitivity to broadly neutralizing antibodies b12, 2G12, 2F5, and 4E10 of primary subtype B human immunodeficiency virus type 1 variants in the natural course of infection
151
Chapter 9 Emergence of b12 resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure
171
Chapter 10 Redirected evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum
Chapter 11 Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies
205
Chapter 12 General discussion 227
Appendix Summary 249
Samenvatting 253
Dankwoord 258
Curriculum Vitae 261
