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Geconcludeerd mag warden dat klikchemie een waardevolle manier is voor biomedische toepassingen. Een van de unieke eigenschappen van klikchemie is het bioorthogonale

karakter. Een snelle covalente koppeling van twee componenten onder milieuvriendelijke en

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ontwikkeling van nieuwe stoffen voor diagnostiek of therapie.

Acknowledgments

After more than 5 years in Groningen, now I'm in the last stage of my thesis, and probably most difficult pages of my thesis. All the work that ended up in my thesis would not have been possible without the support and suggestions of a lot of great people. It is a pleasure to express my gratitude to all the people that made this happen.

First of all I would like to express my deepest gratitude to my first promoter Prof. Dr.

P.H. Elsinga (Philip), who kindly suggested the subject of this study to me, and has been my teacher and supervisor in scientific and technical work. Philip, I thank you for your excellent and tireless guidance, encouragement and patience throughout the years of the study. You have been a wonderful source of knowledge for me. You insistently asked me to remain focused on my work. Your observations and comments helped me to establish the overall direction of the research and to move forward with investigation in depth. You were always there when I need you and you always found time for me in your busy schedule. I thank you for providing me the opportunity to work with talented researchers.

As for you Prof. Dr. B.L Feringa (Ben), I would like to thank you Ben for your guidance, endless creativity, valuable suggestions, patience as well as your sense of humour, support and especially for giving me the opportunity to be a part of your research group.

I would like to thank Prof. Dr. R.A.J.O Dierckx (Rudi) the head of the department of Nuclear Medicine and Molecular Imaging for accepting me as a PhD candidate and giving me the opportunity to work in such a fast developing department. And I'm especially grateful to be given the chance to participate in high quality congresses for opening my mind and sight to the world of nuclear medicine.

Furthermore, I would like to acknowledge the reading committee, Prof. Dr. Heinz Coenen, Prof. Dr Hidde Haisma and Prof. Dr. Gerard Roelfes for their quick revision of the manuscript and their kind suggestions.

I would further like to thank Dr. EFJ de Vries (Erik) for answering many questions over the years, having an open door for chemistry questions and chemical suggestions.

Also a big and special thanks to my dear Lachlan, for having a great work with her as a partner on this project and nice time as a friend during these years. Lachlan, I thank you for all of your help, which was always accompanied by smile. Your support and the energy you gave me during international conferences, while I was nervous before my presentation, is unforgettable.

Acknowlegments

I would like thank to PhD Students and staff of the Stratingh Institute for Chemistry, University of Groningen, in particular to Wiktor Szymanski, Pieter Bos, Anne Schoonen, Lorina Gjonaj, Hans and Teodora for all the useful suggestion and nice time in coffee (tea) time, and also thank you Hilda especially for helping me to make an appointment with Ben in his busy schedule.

I would like to acknowledge to the GUIDE office: Banus and Maaike for helping me with all the papers, organizing courses and for the financial support to attend conferences.

Thanks to the Department of Medical Oncology, in particular to Hetty for hosting me in their lab and for sharing knowledge and equipments with me.

I gratefully acknowledge all the people from the Animal Facility, (CDP) for their help and advice.

Big and warm thanks go to my nice group, Nuclear Medicine and Molecular Imaging department (NGMB). I gratefully thank Ineke for the help in the all bureaucratic steps of my PhD ceremony. As well I would like to acknowledge Annegritt and Annie van Zanten for solving the financial issues during these four years. Klaas Willem thanks a lot for your informatics back-up! Any time I had informatics problem, which happened a lot, you solved my problem immediately.

To all Nuclear Medicine doctors, especially to Jan, Neils, Klaas Pieter and Adrian, thank you for your medical point-of-view given in many occasions. And my gratitude goes to Riemer, Hendrikus and Reza, for their collaboration in the feasibility study of 18F-RGD-KS for ex vivo Imaging of Atherosclerosis.

I would like to thank one of the most experienced scientists that I ever met, Aren. Big thanks for all your suggestion and help, especially for the chapter 4 of my thesis, on FPTC project.

Thanks the physicist group: Prof. Dr. Anne Paans, Antoon, Johan, Sergy, Marcel, Noortje , Michel and especially to my dear friend Roel.

Thank you Gert and Jitze for all your support and solving maintenance problem.

To Hans pol, Hans ter Veen, Arja and Erna, thank you for always having a smile. My special thanks goes to Braaaaaaam © © ©, and Hilda, Michel, Janet, Berta, Joost, Ewout, Marianne, Chantal for the many pleasant days we had in the lab. Especially on Fridays! ! !

I would like to also acknowledge the great contribution of Jurgen for helping with the animal experiment's setup, thanks for teaching me most of the 'pre-clinical' techniques.

Thanks for all your patience.

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Yvonne 2 and the rest of the colleagues in the NGMB department, for having a nice time in coffee break.

To my dear roommates and good friends: Ines, Valentina, Mehrsima, Ania, Daneille, Andrea and Alexandre. I am very happy and lucky to have met you and having such a nice and funny company in these years with you. YOU DON'T KNOW! ! ! but I WILL TELL YOU that, I cannot imagine my time without you in my second home.

I want to thank Giuseppe bello ;), Federica bella ;), David, Erika, Anneik, Reza, Hans, Zilin, Nisha, Katica and Nathalie for all the amazing time that we spent together during and after the working hours.

To the rest of PhD student, Heli, Shiva, Khayum, Siddesh, Soumen Paul, Gaurav, Willem Jan and Vladimir, thank you for all the nice moments we shared.

Thanks to all my friends outside the world of nuclear medicine: Solmaz, Christian, Ghazaleh, Emad, Gabi and Martijn.

To my dear paranymphs Silvana and Janine thank you very much for all your support and help. Thank you for being my good friends since 2007, when I started my PhD project.

I want to thank my lovely sisters, Lida, Zhila and Gilda to be always with me.

Thanks to my dear sister-in-laws Mahta and Elham for having nice conversations.

I want to thank my parents-in-law, to thinking of me during these years. Merci!

And I would like to extend my gratitude to my dear Parents: Sima & Ahmad for their

confidence in me, repeating continuously that I should believe more in myself.

Thank you for your understanding and your endless love. Thank you for understanding a workaholic wife during all the long evenings that I have been working. And you made a delicious dinner with nicely decorated dining table for me. It couldn't be better ...